中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (2): 75-77.

• 论著 •    下一篇

动脉瘤样纤维组织细胞瘤五例临床及病理特征分析

徐秀莲,邵雪宝,陈浩,王千秋,姜祎群,孙建方,曾学思   

  1. 南京 中国医学科学院北京协和医学院皮肤病研究所
  • 收稿日期:2011-04-07 修回日期:2011-08-19 出版日期:2012-02-15 发布日期:2012-01-31
  • 通讯作者: 曾学思 E-mail:xsizeng@yahoo.com.cn

Aneurysmal fibrous histiocytoma: a clinical and histopathologic review of five cases

Xiu-Lian XuShao Xue-Bao2, 2, Yi-Qun JIANG2,   

  • Received:2011-04-07 Revised:2011-08-19 Online:2012-02-15 Published:2012-01-31

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摘要：

目的 探讨动脉瘤样纤维组织细胞瘤的临床特征及组织病理学诊断原则。方法 回顾性分析5例动脉瘤样纤维组织细胞瘤患者的临床及病理资料。结果 5例患者中，男3例，女2例。皮损为暗红色或棕色结节，3例皮损近期突然增大；3例位于四肢，2例位于胸部和下颌。皮损组织病理学检查：均具有典型皮肤纤维瘤的组织学特征，同时见多数不规则出血性裂隙和囊腔结构，伴有含铁血黄素沉积；免疫组化示波形蛋白和CD68阳性，血管性标记（CD34和CD31）均阴性。结论 鉴于AFH临床上具有近期快速增大的特点，组织学上显示出血性裂隙及囊腔形成，该肿瘤需要与血管肉瘤和血管瘤样纤维组织细胞瘤鉴别。

关键词: 临床和病理特征

Abstract:

Objective To understand the clinical and histopathologic diagnostic criteria for aneurysmal fibrous histiocytoma （AFH）. Methods The clinical and histopathological features of 5 patients with AFH were retrospectively reviewed. Results There were 3 males and 2 females in these patients. All the tumors clinically manifested as dark erythematous or brown nodules. Three cases had a recent history of rapid growth. The lesions were located on the limbs （n = 3）, or chest and lower mandible （n = 2）. Histopathological examination of skin biopsies showed typical features of dermatofibroma, accompanied by many irregular cleft-like or cavernous blood-filled spaces with numerous hemosiderin pigments in all of these cases. Immunohistochemically, the tumor cells were immunoreactive to vimentin and CD68 but negative for CD34 or CD31. Conclusions In view of a history of recent rapid growth, the presence of hemorrhagic pseudocysts and high vascularity, AFH should be differentiated from angiosarcoma and angiomatoid fibrous histiocytoma.

Key words: clinical and histological features