中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (2): 145-146.

• 药物与临床 • 上一篇    下一篇

加巴喷丁联合糖皮质激素治疗带状疱疹神经痛的疗效观察

赖亭吉1,施和建2   

  1. 1. 无锡市人民医院皮肤科
    2.
  • 收稿日期:2011-03-22 修回日期:2011-10-12 出版日期:2012-02-15 发布日期:2012-01-31
  • 通讯作者: 赖亭吉 E-mail:ltj19831014@126.com

Clinical efficacy of gabapentin plus glucocorticoids in the treatment of herpes zoster neuralgia

  • Received:2011-03-22 Revised:2011-10-12 Online:2012-02-15 Published:2012-01-31
  • Contact: Ting-Ji LAI E-mail:ltj19831014@126.com

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摘要：

[摘要]目的 观察加巴喷丁联合糖皮质激素治疗对带状疱疹(HZ)后神经痛的疗效。方法 71例HZ患者随机分为两组：试验组(36例)和对照组(35例)。所有患者均给予伐昔洛韦 0.3g BID、甲钴胺胶囊 0.5mg TID、复合维生素B 2片 TID等常规治疗，试验组在此基础上加用加巴喷丁和糖皮质激素治疗。于用药前、用药后第7、15、30天进行直观模拟尺评分法(VAS)，评价患者的疼痛治疗效果和HZ后神经痛的发生率。结果 试验组VAS评分在用药后第7、15、30天分别为(4.78±0.99)、(3.69±1.31)和(2.50±1.32)，均显著低于对照组同期的(7.40±1.22)、(6.68±1.18)和(5.49±1.34)，也低于试验组用药前的(7.72±0.88)，在统计学上组间差异有显著性(P<0.01)。随访3个月，试验组HZ后神经痛的发生率为5.5%，明显低于对照组的31.4%，在统计学上组间差异有显著性 (P<0.01)。结论 在常规治疗的基础上，加用加巴喷丁联合糖皮质激素治疗对于HZ的神经痛疗效满意，可以明显减少HZ后神经痛的发生。

关键词: 神经痛

Abstract:

[Abstract] Objective To observe the efficacy of gabapentin combined with glucocorticosteroids in treatment of postherpetic neuralgia.Methods seventy one patients with herpes zoster(HZ) were divided into two groups: test group (36 cases)and control group (35 cases) at random. All patients were treated with valaciclovir 0.3g BID, methylcobalamin capsules 0.5mg TID, complex vitamin B 2 slices TID and other conventional treatment.The test group was treated with gabapentin and glucocorticosteroids on this basis. The clinical effect of pain and incidence rate of postherpetic neuralgia was evaluated before and after 7,15,30 days of treatment by visual analogue scale (VAS). Results The VAS was significantly decreased in the test group 7,15,30 days after treatment than those in the control group (4.78±0.99 vs 7.40±1.22 , 3.69±1.31 vs 6.68±1.18, 2.50±1.32 vs 5.49±1.34, respectively, all P<0.01). The VAS was obviously lower in the test group 7,15,30 days after treatment than before treatment (4.78±0.99 vs 7.72±0.88, 3.69±1.31 vs 7.72±0.88, 2.50±1.32 vs 7.72±0.88, respectively, all P<0.01).In addition, after three months’ follow-up, the incidence rate of postherpetic neuralgia was significantly lower in the test group than in the control group(5.5% vs 31.4%, P<0.01). Conclusions On the basis of conventional therapy,addition of gabapentin combined with glucocorticosteroids in treatment of postherpetic neuralgia was effective,it can significantly reduce the incidence of postherpetic neuralgia.

Key words: Neuralgia