中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (2): 140-141.

• 中医中药 • 上一篇    下一篇

“血分论治”寻常性银屑病患者外周血白介素17和白介素23的变化

陈晋广1,杨志波2   

  1. 1. 浙江省台州市市立医院皮肤科
    2. 湖南中医药大学附属第二医院
  • 收稿日期:2011-03-02 修回日期:2011-10-17 出版日期:2012-02-15 发布日期:2012-01-31
  • 通讯作者: 陈晋广 E-mail:tongly0422@126.com
  • 基金资助:

    国家自然基金(NO. 30873273);浙江省医药卫生科技计划（NO. 2010KYB129）

Changes of interleukin-17 and -23 protein expressions in peripheral blood from patients with psoriasis vulgaris receiving traditional Chinese hemo-modulating therapy

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  • Received:2011-03-02 Revised:2011-10-17 Online:2012-02-15 Published:2012-01-31

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摘要：

[摘要]目的：从Th17细胞角度研究“血分论治” 银屑病的作用机制。方法：选择32例寻常型银屑病患者（血热证组17例，血瘀证组15例），15例健康人为对照组,分别给予清热凉血方、益气活血方治疗。各组分别于治疗前后应用酶联免疫吸附方法(ELISA)检测患者外周血Th17相关细胞因子白细胞介素(IL)-17和IL-23的表达。结果：银屑病患者IL-17、IL-23表达水平明显高于对照组。中药治疗后，两组患者IL-17、IL-23表达水平均明显下降。结果：从“血分论治” 寻常型银屑病可通过调节IL-17、IL-23水平发挥治疗作用。

关键词: IL-23

Abstract:

Experimental Study on Blood-Stage Treatment on Influencing IL-17、 IL-23 in Patients with Psoriasis Vulgaris CHEN Jin-guang.Department of Dermatology,Zhe Jiang Tai Zhou Municipal Hospital,Taizhou 318000, China. ZHU Ming-fang,YANG Zhi-bo. Second Affiliated Hospital Hunan Chinese Medical College, Chang Sha 410005,hunan, China. Abstract: Objective：To investigate the action mechanisma of blood-stage treatment in the influence of psoriasis vulgaris from Th17. Methods:32 patients were observed and 15 healthy people were enrolled as control. Th17-related plasma cytokine(IL-17、IL-23) concentrations were measured by enzyme-linked immunosorbent assay(ELISA) before and after treated by heat-clearing and blood-cooling decoction、qi-enriching and blood-activating decoction. Results: Th17 related cytokine IL-17 and IL-23 markedly increased in psoriasis compared with controls.After herbal treatment, IL-17、IL-23 expression decreased.Conclusion: Blood-stage treatment works well on IL-17、IL-23 expression in patients with psoriasis vulgaris.

Key words: IL-23