中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (2): 130-132.

• 研究报道 • 上一篇    下一篇

玫瑰糠疹患者外周血淋巴细胞Toll样受体3、7、9的表达

杨帆1,韩秀萍2   

  1. 1. 中国医科大学附属盛京医院
    2. 中国医科大学附属盛京医院皮肤科
  • 收稿日期:2011-04-18 修回日期:2011-08-07 出版日期:2012-02-15 发布日期:2012-01-31
  • 通讯作者: 韩秀萍 E-mail:hanxiuping66@126.com

Expressions of Toll-like receptor 3, 7 and 9 in peripheral blood lymphocytes from patients with pityriasis rosea

Fan YANG1,   

  • Received:2011-04-18 Revised:2011-08-07 Online:2012-02-15 Published:2012-01-31

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摘要：

目的 探讨Toll样受体在玫瑰糠疹发病中的作用。方法 选择玫瑰糠疹患者40例以及正常对照者40例， RT-PCR方法检测外周血淋巴细胞中TLR3、7、9 mRNA的表达情况。结果 玫瑰糠疹患者TLR3、7、9的mRNA与正常人对照组相比表达均升高，差异有统计学意义（P < 0.05）。玫瑰糠疹组TLR3与TLR7，TLR3与TLR9呈正相关性（P < 0.05）。玫瑰糠疹组TLR7与TLR9，以及对照组TLR3、7、9之间无相关性。结论 玫瑰糠疹发病可能与病毒通过Toll样受体途径作用于机体免疫系统有关。

关键词: RT-PCR

Abstract:

Objective To explore the roles of Toll-like receptor （TLR） 3, 7 and 9 in the pathogenesis of pityriasis rosea. Methods This study recruited 40 patients with pityriasis rosea and 40 normal human controls. Reverse transcription-PCR was carried out to detect the expressions of TLR3, 7 and 9 in peripheral blood lymphocytes of these subjects. Results The mRNA expressions of TLR3, 7 and 9 in peripheral blood lymphocytes were significantly higher in patients with pityriasis rosea than in the normal human controls（Z = 4.239, 3.745, 2.658, all P < 0.05）. There was a positive correlation between the expression of TLR3 and TLR7 （r = 0.574, P < 0.01） as well as between that of TLR3 and TLR9（r = 0.551, P < 0.01） in the patients, while there was no correlation between TLR7 and TLR9 expression in the patients or between the expressions of TLR3, TLR7 and TLR9 in the controls. Conclusion Virus infection might be involved in the pathogenesis of pityriasis rosea via TLR pathways.

Key words: RT-PCR

中图分类号: 

  • R758.64