尖锐湿疣组织内血管内皮生长因子和转化生长因子-α表达

中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (5): 350-351.

尖锐湿疣组织内血管内皮生长因子和转化生长因子-α表达

郑双进¹,黎兆军²,樊翌明²

1. 现在河南科技大学第二附属医院
2. 湛江广东医学院附属医院皮肤科

收稿日期:2010-06-28 修回日期:2010-08-26 出版日期:2011-05-15 发布日期:2011-05-03
通讯作者: 黎兆军 E-mail:skindoctor@163.com
基金资助:
广东省2005年（财政）科技三项基金资助项目

Expressions of vascular endothelial growth factor and tranforming growth factor-α in condyloma acuminatum tissues

Received:2010-06-28 Revised:2010-08-26 Online:2011-05-15 Published:2011-05-03

摘要/Abstract

摘要：

目的探讨血管内皮生长因子（VEGF）和转化生长因子-α（TGF-α）在尖锐湿疣（CA）血管形成中的作用。方法用RT-PCR 和免疫组化法检测30例CA和15例正常包皮中VEGF、TGF-α和CD34表达。结果 CA中VEGF和TGF-α mRNA表达明显高于正常包皮（P < 0.001）；CA中VEGF、TGF-α蛋白阳性表达率分别为90%、86.7%，正常包皮中则为40%、26.7%，二者的差异具有统计学意义（P < 0.01）。CA中微血管密度比正常包皮明显增多（P < 0.01），且CA中VEGF、TGF-α蛋白表达与MVD呈显著正相关（P < 0.01）。结论 CA中VEGF和TGF-α表达上调，可能促进血管生成，参与CA的发生、发展。

关键词: 尖锐湿疣

Abstract:

Objective To investigate the role of vascular endothelial growth factor （VEGF） and transforming growth factor-α （TGF-α） in the angiogenesis of condyloma acuminatum （CA）. Methods Tissue specimens were obtained from the lesions of 30 patients with CA and foreskin of 15 normal human controls. Reverse transcription （RT）-PCR and immunohistochemical method were utilized to measure the protein and mRNA expressions of VEGF and TGF-α in the specimens. Microvessel density（MVD） was determined by staining with anti-CD34 polyclonal antibodies. Results A statistical elevation was observed in the expression of VEGF and TGF-α mRNA as well as MVD in CA specimens compared with the normal control specimens （P < 0.001, 0.001, 0.01）. The expressions of VEGF and TGF-α protein were observed in 90% and 86.7% of the CA specimens, and in 40% and 26.7% of the control specimens （both P < 0.01）. MVD was positively correlated with the expression of VEGF and TGF-α protein in CA tissues （both P < 0.01）. Conclusion The overexpression of VEGF and TGF-α in CA tissue may accelerate angiogenesis in, and participate in the development and progression of, CA.

Key words: condyloma acuminatum

郑双进黎兆军樊翌明. 尖锐湿疣组织内血管内皮生长因子和转化生长因子-α表达[J]. 中华皮肤科杂志, 2011, 44(5): 350-351.

参考文献

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