中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (2): 77-79.

• 论著 • 上一篇    下一篇

小汗腺螺旋腺癌一例

顾黎雄1,吴晓琰1,曹双林2,蒋海娟3,陈浩4,沈聪聪5,陈晓栋2   

  1. 1. 南通大学附属医院
    2. 南通大学附属医院皮肤科
    3. 江苏省如东县第四人民医院
    4. 南京 中国医学科学院北京协和医学院皮肤病研究所
    5. 南通大学医学院;南通大学附属医院皮肤科
  • 收稿日期:2010-06-17 修回日期:2010-07-20 出版日期:2011-02-15 发布日期:2011-02-10
  • 通讯作者: 陈晓栋 E-mail:dermatochen@163.com

Eccrine spiradenocarcinoma: a case report

  • Received:2010-06-17 Revised:2010-07-20 Online:2011-02-15 Published:2011-02-10
  • Contact: Chen Xiao-Dong E-mail:dermatochen@163.com

摘要:

患者女,70岁。40年前发现左颈部、躯干出现数个皮肤肿物,10余年前手术切除数个,术后复发并增多,2个月前肿物出现持续性钝痛,10 d前左颈部肿物出现破溃。组织病理学检查见真皮内肿瘤细胞团块,中央为良性小汗腺螺旋腺瘤的成分,周边为恶性肿瘤成分,恶性肿瘤成分中细胞轻度异形伴透明变性。免疫组化显示,癌胚抗原和上皮膜抗原呈阳性表达。诊断为小汗腺螺旋腺癌。手术切除后1个月复发,3个月复发的肿瘤增多增大,并出现破溃,术后6个月死亡。

关键词: 诊断,病理学

Abstract:

A 70-year-old female patient presented with several cutaneous masses on the left neck and trunk for 40 years. Some masses were removed by surgical operation more than 10 years prior to the presentation, but recurred subsequently along with an increase in lesion number. Persistent dull pain emerged at the lesion sites 2 months prior to the presentation and the masses on the left neck ulcerated 10 days prior to the presentation. Histopathology showed tumor cell clumps in the dermis with benign eccrine spiradenoma components in the centre region and carcinomatous components in the periphery. The carcinomatous components included slightly atypical cells and hyaline degeneration. Immunohistochemically, carcinoembryonic antigen and epithelial membrane antigen were observed in the tumor tissues. The case was diagnosed as eccrine spiradenocarcinoma. The masses were surgically removed, but recurred 1 month later, increased in size and number and ulcerated 3 months later, and the patient died 6 months after the surgery.

Key words: Diagnosis, pathology