中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (11): 807-808.

• 研究报道 • 上一篇    下一篇

尖锐湿疣患者外周血单一核细胞中干扰素调节因子7和Toll样受体9 mRNA的表达

刘玉1,王丽1,王玉丽2   

  1. 1. 山西医科大学第二医院皮肤科
    2. 山西省太原市新建南路56号山西医科大学
  • 收稿日期:2010-11-18 修回日期:2011-06-11 出版日期:2011-11-15 发布日期:2011-11-01
  • 通讯作者: 王丽 E-mail:TyWangLi@yeah.net

Expressions of interferon regulatory factor 7 and Toll-like receptor 9 in peripheral blood mononuclear cells (PBMCs) of patients with condyloma acuminatum

  • Received:2010-11-18 Revised:2011-06-11 Online:2011-11-15 Published:2011-11-01

摘要:

目的 探讨干扰素调节因子7、Toll样受体9在尖锐湿疣发病中的作用及临床意义。方法 采用逆转录聚合酶链反应检测25例尖锐湿疣患者外周血单一核细胞中干扰素调节因子7、Toll样受体9 mRNA的水平,20例正常人作对照。结果 尖锐湿疣患者外周血单一核细胞中干扰素调节因子7与Toll样受体9 mRNA表达水平均明显高于正常对照组,差异有统计学意义(P值均 < 0.01)。结论 尖锐湿疣患者外周血中干扰素调节因子7、Toll样受体9表达升高。

关键词: 单核细胞

Abstract:

Objective To investigate the role and clinical significance of interferon regulatory factor 7 (IRF7) and Toll-like receptor 9 (TLR9) in the development of condyloma acuminatum (CA). Methods Reverse transcription-PCR was performed to analyze the mRNA expressions of IRF7 and TLR9 in peripheral blood mononuclear cells (PBMCs) of 25 patients with CA and 20 normal human controls. Results The expression levels of IRF7 and TLR9 mRNA in PBMCs were significantly higher in the patients with CA than in the controls (both P < 0.01). Conclusion There is a significant increase in the expression of IRF7 and TLR9 in the PBMCs of patients with CA.

Key words: Monocytes

中图分类号: 

  • R752.5+3