皮肤免疫系统与光致癌

摘要/Abstract

摘要：

紫外线对皮肤具有光致癌作用，可以诱发多种皮肤恶性肿瘤。皮肤免疫系统包括朗格汉斯细胞、肥大细胞、淋巴细胞、角质形成细胞等细胞成分，以及细胞因子、补体、前列腺素等体液成分。皮肤免疫系统对维持皮肤微环境的稳定具有非常重要的作用。紫外线辐射可以引起皮肤免疫系统的功能异常，其中由其诱发的免疫抑制、抗原提呈功能异常和免疫监视功能减弱与光致癌的发生具有密切的联系。目前的研究说明皮肤免疫系统的多种组成部分参与了光致癌发生。皮肤免疫系统与紫外线光致癌的关系研究，对于深入揭示紫外线光致癌作用和应用免疫学相关手段预防和治疗紫外线相关恶性肿瘤具有及其重要的意义。

关键词: 光致癌

Abstract:

Ultraviolet radiation can induce skin photocarcinogenesis. Skin immune system (SIS) is consist of immune cells and humoral components. Cell components of SIS include langerhan’s cell, mast cell, lymphocyte, keratinocyte, and others. Humoral components of SIS include cytokine, complement, prostaglandin and others. SIS plays an essential role of maintaining skin homeostasis. Ultraviolet radiation can damage the function of SIS for antigen presenting and immunosurveillance, and induce immunosuppression. These all can initiate and promote the Ultraviolet-related skin carcinogenesis. Research on SIS is important to elucidate the mechanism of photocarcinogenesis. Furthermore, we can apply immunological methods to prevent and treat the ultraviolet-related skin carcinogenesis.

Key words: photocarcinogenesis

陈旭齐蓓黄丹顾恒. 皮肤免疫系统与光致癌[J]. 中华皮肤科杂志, 2011, 44(1): 64-66.

Qi Bei HUANG Dan. Skin immune system and photocarcinogenensis[J]. Chinese Journal of Dermatology, 2011, 44(1): 64-66.

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