慢性荨麻疹患者粉尘螨变应原皮肤点刺反应与自体血清皮肤反应的关系

中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (1): 15-17.

慢性荨麻疹患者粉尘螨变应原皮肤点刺反应与自体血清皮肤反应的关系

黄秀英¹,周小芳²,冯林¹,钟华³,宋志强³,郝飞⁴

1. 重庆第三军医大学西南医院皮肤科
2.
3. 第三军医大学西南医院皮肤科
4. 重庆第三军医大学西南医院皮肤科

收稿日期:2010-06-07 修回日期:2010-08-12 出版日期:2011-01-15 发布日期:2011-01-10
通讯作者: 宋志强 E-mail:drsongzq@hotmail.com

Relationship between skin prick test reactivity to dermatophagoides farinae and autologous serum reactivity in patients with chronic urticaria

Received:2010-06-07 Revised:2010-08-12 Online:2011-01-15 Published:2011-01-10
Contact: Zhiqiang Song E-mail:drsongzq@hotmail.com

摘要/Abstract

摘要：

目的探讨自体血清的自身反应和粉尘螨诱发的变态反应在慢性荨麻疹（CU）发病中的作用和相关性。方法对831例CU患者同时进行自体血清皮肤试验（ASST）及粉尘螨皮肤点刺实验（SPT），对ASST与粉尘螨变应原阳性之间的相关性进行分析。结果 831例CU患者ASST和粉尘螨的总阳性率分别为51.74%和64.62%，ASST阳性组和阴性组粉尘螨SPT阳性率分别为56.52%和73.86%，两组差异有统计学意义（P < 0.05）。ASST阳性组中ASST阳性程度和粉尘螨SPT阳性程度呈负相关性（P < 0.05）。结论自体血清皮肤反应和粉尘螨变应原诱发的变态反应均在慢性荨麻疹的发病机制中呈负相关，对CU患者同时进行变应原和ASST检测有助于临床分型和治疗。

关键词: 变态反应

Abstract:

Objective To investigate the role of and relationship between reactivity to autologous serum and dermatophagoides farinae （Df） in the pathogenesis of chronic urticaria （CU）. Methods Autologous serum skin test （ASST） and skin prick test （SPT） to Df were carried out in 831 patients with CU. The correlation between reactivity to autologous serum and Df was statistically analyzed. Results The positivity rate of ASST and SPT to Df was 51.74% and 64.62%, respectively in the 831 patients. SPT was positive in 56.52% of patients with positive ASST and in 73.86% of those with negative ASST （P < 0.05）. In patients with positive ASST, the degree of autologous serum reactivity was negatively correlated with that of reactivity to Df （P < 0.05）. Conclusions The skin reactivity to Df and autologous serum plays an important role in the pathogenesis of CU, and the degree of the reactivity to Df and autologous serum is negatively correlated. To conduct ASST and SPT simultaneously in patients with CU may favor the clinical classification and therapy of CU.

Key words: allergic reaction

黄秀英周小芳冯林钟华宋志强郝飞. 慢性荨麻疹患者粉尘螨变应原皮肤点刺反应与自体血清皮肤反应的关系[J]. 中华皮肤科杂志, 2011, 44(1): 15-17.

参考文献

1. Sabroe RA, Francis DM,et al. The autologous serum shin test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol, 1999, 140(3):446-452. 2. G. N. Konstantinou, R. Asero,M. Maurer, R. A. Sabroe,P. Schmid-Grendelmeier,C. E. H. Grattan. EAACI/GA2LEN task force consensus report: the autologous serum skin test in urticaria. Allergy，2009: 64(9): 1256–1268. 3. 木其日,刘玲玲,梁玉华,朱学骏.慢性特发性荨麻疹患者自体血清皮肤试验结果分析.临床皮肤科杂志，2003,32(11):645-647. 4. Caliskaner Z, Ozturk S, Turan M, et al. Skin test positivity to aeroallergens in the patients with chronic urticaria without allergic respiratory disease. J Investig Allergol Clin Immunol, 2004, 14(1): 50-54. 5. 周小芳,黄秀英,尹锐等.重庆地区过敏性鼻炎变应原点刺试验222例结果分析. 中华医学实践杂志，2009:8(11):667-669. 6. M?ynek A, Maurer M, Zalewska A.Update on chronic urticaria: focusing on mechanisms.Curr Opin Allergy Clin Immunol. 2008;8(5):433-437. 7. Najib U, Sheikh J.The spectrum of chronic urticaria.Allergy Asthma Proc，2009;30(1):1-10 8. Caproni M, Volpi W, Macchia D, Giomi B, Manfredi M, Campi P, Cardinali C, D'Agata A, Fabbri P.Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test.Exp Dermatol，2003;12(5):621-628. 9. 孙蔚凌，毕志刚。自体血清皮肤试验阳性与阴性慢性荨麻疹患者临床特点分析。中华皮肤科杂志，2005，38(6):342-344 10. 宋志强，包婵妮，翟志芳，钟华，钟白玉，郝飞。特异性免疫治疗对屋尘螨特异性IgE抗体阳性慢性荨麻疹的疗效观察。临床皮肤科杂志，2008；37(12):809-811. 11. Staubach P, Onnen K, Vonend A, Metz M, Siebenhaar F, Tschentscher I, Opper B, Magerl M, Lüdtke R, Kromminga A, Maurer M.Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: a placebo-controlled trial.Dermatology，2006;212(2):150-159. 12. Bajaj AK, Saraswat A, Upadhyay A, Damisetty R, Dhar S. Autologous serum therapy in chronic urticaria: Old wine in a new bottle. Indian J Dermatol Venereol Leprol，2008 26;74(2):109-113

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