中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (9): 660-661.

• 病例报告 • 上一篇    下一篇

拟诊Weary-Kindler综合征一例

连昕1,冯爱平1,陈善娟2,黄长征3,王椿森1   

  1. 1. 华中科技大学同济医学院附属协和医院
    2.
    3. 华中科技大学同济医学院附属协和医院皮肤科
  • 收稿日期:2010-01-20 修回日期:2010-04-20 发布日期:2010-09-10
  • 通讯作者: 冯爱平 E-mail:arztfeng@126.com

Suspected Weary-Kindler syndrome: a case report

  • Received:2010-01-20 Revised:2010-04-20 Published:2010-09-10

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摘要：

患者男，51岁，全身红斑、角化、皮肤异色、肢端水疱7年余，并伴有皮肤萎缩、光敏感、并指、粘膜损害、甲破坏、眼睑内翻、掌趾角化、假阿洪病、龋齿。皮肤病理：表皮角化过度，表皮萎缩，基底细胞液化变性，可见胶样小体。可见一处皮下裂隙，真皮浅层可见大量游离色素和嗜色素细胞。拟诊：Weary-kindler综合征。

关键词: Weary-kindler综合征, 肢端角化性皮肤异色病

Abstract:

A 51-year old male patient, who was suffered from extensive erythema, keratoderma, poikiloderma and acral blister formation for seven years, together with skin atrophy, photosensitivity, syndactyly, mucosal involvement, nail dystrophy, entropion of the eye lids, palmoplantar keratoderma, pseudoainhum and dental caries. Histopathology examination showed mild hyperkeratosis and atrophy of the epidermis, liquefaction degeneration of basal cell and colloid bodies. There was a subepidermal cleft, many melanophages and free pigments were observed in upper dermis. Suspected diagnosis: Weary-kindler syndrome.

Key words: Weary-kindler syndrome, acrokeratotic poikiloderma