中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (7): 467-470.

• 论著 • 上一篇    下一篇

胰岛素样生长因子ⅡmRNA结合蛋白3在恶性黑素瘤及良性痣中的表达

辛崇美1,徐秀莲1,李阿梅2,姜祎群1,陈浩1,曾学思1,孙建方1   

  1. 1. 南京 中国医学科学院北京协和医学院皮肤病研究所
    2. 南京市 中国医学科学院皮肤病研究所
  • 收稿日期:2009-11-06 修回日期:2010-03-14 出版日期:2010-07-15 发布日期:2010-07-13
  • 通讯作者: 辛崇美 E-mail:xincmay@yahoo.com.cn
  • 基金资助:

    国家自然科学基金;国家教委高校博士点基金

Expression of insulin-like growth factor-Ⅱ（IGF-Ⅱ） mRNA-binding protein-3 in malignant melanoma and benign nevi

  • Received:2009-11-06 Revised:2010-03-14 Online:2010-07-15 Published:2010-07-13

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摘要：

目的 探讨胰岛素样生长因子Ⅱ mRNA结合蛋白3（IMP3）在良性痣及黑素瘤组织中的表达，及其在恶性黑素瘤进展及诊断中的作用。方法 用IMP3抗体对28例恶性黑素瘤、8例Spitz痣、6例发育不良性痣和25例良性痣患者的标本组织进行免疫组化研究。结果 28例恶性黑素瘤组织标本中23例IMP3阳性，8例Spitz痣中4例阳性，6例发育不良性痣中2例阳性，25例良性痣均不表达。IMP3在黑素瘤中的表达明显高于Spitz痣及发育不良性痣（P < 0.05），侵袭性黑素瘤表达明显高于原位黑素瘤（P < 0.01）。结论 IMP3可能是良性痣发展至恶性黑素瘤的一个生物学标志，在鉴别黑素瘤和良性痣之间存在一定的价值。

关键词: 关键词：IMP-3, 恶性黑素瘤（MM）, 良性痣, 免疫组化

Abstract:

Objective To investigate the expression of insulin-like growth factor-Ⅱ（IGF-Ⅱ） mRNA-binding protein-3（IMP3） in tissue of benign nevi and malignant melanoma, and to evaluate the role of IMP3 in the development and diagnosis of malignant melanoma. Methods Immunohistochemistry was performed to measure the expression of IMP3 in tissue samples from 28 cases of malignant melanoma, 8 Spitz nevi, 6 dysplastic nevi and 25 benign nevi. Results Immunohistochemically, IMP3 was observed in 23 of 28 melanoma samples, 4 of 8 Spitz nevus samples and 2 of 6 dysplastic nevus samples, but not in benign nevus samples. The expression level of IMP3 was significantly higher in tissue of melanoma than in that of Spitz nevi and dysplastic nevi （both P < 0.05）, also higher in tissue of aggressive melanoma than that of melanoma in situ（P < 0.01）. Conclusions IMP3 seems to be a biomarker for the progression of benign nevi to malignant melanoma, and may be utilized to distinguish melanoma from benign nevi.

Key words: [Key words] IMP3, malignant melanoma, benign nevi, immunohistochemistry