中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (4): 289-289.
• 病例报告 • 上一篇 下一篇
王桂芝1,潘敏2,史同新3,王君1
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摘要:
痣样基底细胞癌综合征是一种罕见的常染色体显性遗传病,以泛发性皮肤基底细胞癌和多器官发育异常为主要临床特征。本文报告1例痣样基底细胞癌综合征患者,并结合相关文献对该病的发病率、发病机制、诊断标准、治疗方法等进行讨论。
关键词: 痣样基底细胞癌综合征, 基底细胞癌
Abstract:
[Abstract] Objective To report a case of nevoid basal cell carcinoma syndrome and discuss its incidence, pathogenesis, clinical features and treatment. Methods Skin specimens were obtained from the patient and examined by histopathology , and relevant literatures were reviewed. Results A 48-year-old female presented with a 40-year history of with decades of crusted macules, varying in color from pink to brown and ranging in size from 0.5 to 3 mm in diameter, together with palmar keratotic plaques. Histopathology of skin specimens on the chest, abdomen and back revealed the presence of nests and lobules of basophile cells orderly settled, with a great amount of melanin pigmentation. The patient is mending after 3-month treatment with oral retinoid therapy . Conclusions The case is diagnosed as nevoid basal cell carcinoma syndrome by clinical features and histopathology findings, and was effectively treated by retinoic acid.
Key words: nevoid basal cell carcinoma syndrome, basal cell carcinoma
王桂芝 潘敏 史同新 王君. 痣样基底细胞癌综合征一例[J]. 中华皮肤科杂志, 2010, 43(4): 289-289.
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