中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (3): 213-214.

• 病例报告 • 上一篇    下一篇

原发性皮肤间变性大细胞淋巴瘤一例

杜宇1,许飏2,廖勇梅3,裴保强2,熊霞4   

  1. 1. 泸州医学院附属医院
    2. 四川省泸州医学院附属医院皮肤科
    3.
    4. 四川省泸州医学院附院皮肤科
  • 收稿日期:2009-03-17 修回日期:2009-06-09 出版日期:2010-03-15 发布日期:2012-03-31
  • 通讯作者: 杜宇 E-mail:duyu86@21cn.com

A case of primary cutaneous anaplastic large cell lymphoma

  • Received:2009-03-17 Revised:2009-06-09 Online:2010-03-15 Published:2012-03-31

摘要:

[摘要]报告1例原发性皮肤CD30+大细胞性淋巴瘤。右前臂皮肤红肿浸润、溃疡结痂1月,左侧头面部红肿浸润10天。右前臂皮损组织病理检查:真皮深层以及皮下脂肪组织间瘤细胞浸润,密集分布。瘤细胞胞质丰富,呈嗜酸性,部分呈空泡状,细胞核大,异型性明显,核仁明显,染色质呈粗颗粒状,并可见病理性核分裂象;有少量成熟淋巴细胞浸润。行免疫组化检查示: 瘤细胞CD45R0(+)、CD30(+),CD68(-)、CD20(-)、EMA(-)及ALK(-)。诊断为原发性皮肤间变性大细胞淋巴瘤

关键词: 皮肤表现

Abstract:

This paper reports one case of primary cutaneous CD30 + large cell lymphoma. The right forearm skin appears inflammation, infiltration and ulcer incrustation for one month; the left head and face appear inflammation and infiltration for ten days. Pathological examination on right forearm cutaneous lesions: at the deep dermal layer and between subcutaneous adipose tissues the tumor cells appear infiltration and intensive distribution; the tumor cells are rich in cytoplasm and are eosinophilic; some show vacuoles shape, big nucleus, obvious atypia and obvious nucleoli, the chromatin showing coarse granular shape, and there is pathological karyokinesis; a small amount of sophisticated lymphocytic appear infiltration. Immunohistochemistrical examination shows tumor cells CD45R0 (+), CD30 (+), CD68 (-), CD20 (-), EMA (-) and ALK (-). Thus it is diagnosed as Primary Cutaneous Anaplastic Large Cell Lymphoma