中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (3): 208-209.

• 临床经验 • 上一篇    下一篇

外用1%吡美莫司乳膏治疗白癜风临床疗效观察

罗显雁1,许爱娥2,李金超3   

  1. 1. 杭州市第三人民医院
    2. 安徽医科大学附属杭州市第三人民医院皮肤科
    3.
  • 收稿日期:2009-04-13 修回日期:2009-10-30 出版日期:2010-03-15 发布日期:2012-03-31
  • 通讯作者: 罗显雁 E-mail:luoxy123@163.com
  • 基金资助:

    CpG-ODN经Akt/mTOR抗UVB诱导的角质形成细胞凋亡的保护机制研究

Clinical efficacy of pimecrolimus cream 1% in the treatment of vitiligo

  • Received:2009-04-13 Revised:2009-10-30 Online:2010-03-15 Published:2012-03-31

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摘要：

【摘要】：目的：观察局部外用1%吡美莫司乳膏治疗白癜风的临床疗效及安全性。方法：给予49例白癜风患者1%吡美莫司乳膏，每日2次外用，每两个月随访一次，观察治疗后靶皮损复色情况。结果：49例患者共计53处皮损，外用1%吡美莫司乳膏4-6个月后，22例达到不同程度的复色，有效率为55.10％，显效率为22.45%。除了2例患者用药后出现面部痤疮，其它无任何不良反应。结论：局部外用1%吡美莫司乳膏治疗白癜风疗效较好，不良反应少。

关键词: 吡美莫司

Abstract:

【Abstract】Objective: To evaluate the therapeutic effects and safety of 1% pimecrolimus ointment for patients with vitiligo．Methods: Topical 1% pimecrolimus ointment was applied to the vitiliginous patches in 49 patients with vitiligo，twice daily for 1 to 4 months ,the grade of repigmentation was evaluated at an interval of 2 month．Results: 22 of the total 49 vitiliginous patients(55.10％) experienced some repigmentation．50 percent(11/49)of the patients achieved a successful response(≥50％ repigmentation)．The medication was well tolerated except that 2 patients experienced acne-like lesions．Conclusion: Topical pimecrolimus ointment proved to be an effective alternative therapy for vitiligo, Because it does not produce atrophy or other adverse effect．

Key words: pimecrolimus