中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (5): 292-295.

• 论著 • 上一篇    下一篇

生殖支原体与黏液脓性宫颈炎相关性的研究

其木格 蒋法兴 王千秋 苏晓红   

  1. 南京市医科院皮研所
  • 收稿日期:2007-11-09 修回日期:2008-01-22 发布日期:2008-05-15
  • 通讯作者: 其木格 E-mail:qigegemail@yahoo.com.cn

The Study of association between mycoplasma genitalium and mucopurulent cervicitis

  

  • Received:2007-11-09 Revised:2008-01-22 Published:2008-05-15

PDF

148

摘要： 目的 探讨生殖支原体与女性非衣原体非淋球菌感染的黏液脓性宫颈炎的相关性。方法 对象包括性病门诊就诊的女性非衣原体非淋球菌感染的黏液脓性宫颈炎患者226例及健康体检人群118例。采集宫颈拭子标本，运用PCR检测生殖支原体。一般情况、病史和性行为等采用问卷调查。结果生殖支原体在非衣原体非淋球菌感染的黏液脓性宫颈炎患者中的检出率为11.06%（25/226），健康体检人群中的检出率为0.85%（1/118），两组间差异有统计学意义（χ2 = 11.58，P < 0.001）。分析226例黏液脓性宫颈炎患者显示，有异位妊娠史、宫颈糜烂、附件压痛及宫颈内管分泌物镜检多型核白细胞≥10个/油镜视野的患者生殖支原体的感染率分别为27.78%，16.36%，18.28%，14.12%，而无异位妊娠史、宫颈糜烂、附件压痛及宫颈内管分泌物镜检多型核白细胞 < 10个/油镜视野的患者分别为9.62%，6.03%，6.02%，1.79%，生殖支原体的感染率差异在四组人群间均有统计学意义（P < 0.05），而多性伴数和宫颈口有黏液脓性分泌物在两组间差异均具有统计学意义（P < 0.01）。结论 性病门诊就诊的非衣原体非淋球菌感染黏液脓性宫颈炎患者中，生殖支原体感染率高于普通人群。

关键词: 生殖支原体, 黏液脓性宫颈炎

Abstract: Objective To study the relationship between M. genitalium and nongonococcal, non- chlamydial mucopurulent cervicitis. Methods A total of 226 patients with nongonococcal, nonchlamydial mucopurulent cervicitis and 118 healthy female volunteers were recruited in this study. Cervical samples were collected and M.genitalium was detected by PCR amplification of 16s rRNA and Pa genes. Information about socio-demographic characteristics, medical history, and sexual behaviors was gathered by questionnaire from both populations. Results The prevalence of M. genitalium infection was 11.06% （25/226） in patients with mucpurulent cervicitis, 0.85% （1/118） in the healthy controls; the difference was significant between the two groups（χ2 = 11.58, P < 0.001）. Single variant analysis on the 226 patients showed that the prevalence of M. genitalium infection was 27.78%, 16.36%, 18.28% and 14.12% in patients with ectopic pregnancy history, cervical inflammation, pelvic organ tenderness, 10 or more polymorphonuclear leukocytes （PMNs） per oil immersion field in cervical discharge, respectively, significantly higher than that in patients without ectopic pregnancy history, cervical inflammation or pelvic organ tenderness, and those with less than 10 PMNs per oil immersion field in cervical discharge （9.62%, 6.03%, 6.02% and 1.79%, all P < 0.05）. M.genitalium infection was also related to multiple sex partners and the presence of mucopurulent secretion in cervix （P < 0.001）. Conclusion The prevalence of M.genitalium infection is higher in patients with nongonococcal, nonchlamydial mucopurulent cervicitis attending STD clinic than that in normal population.