中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (12): 831-832.

• • 上一篇    下一篇

壮族人寻常性银屑病与HLA-DQA1和DQB1基因的相关性研究

郑文军 温斯健 林有坤 潘尚领   

  1. 南宁广西医科大学第一附属医院皮肤科 广西医科大学第一附属医院 广西医科大学 广西医科大学
  • 收稿日期:2008-02-18 修回日期:2008-03-24 发布日期:2008-12-15
  • 通讯作者: 郑文军 E-mail:zhengwenjun2006@163.com

Relationship of HLA-DQA1, -DQB1 loci to psoriasis vulgaris in Zhuang nationality population

Sijian Wen Youkun Lin Shangling Pan   

  • Received:2008-02-18 Revised:2008-03-24 Published:2008-12-15

PDF

46

摘要： [摘要]目的：探讨广西壮族人寻常型银屑病的发病与HLA-DQA1和DQB1基因的关联。方法：应用聚合酶链式反应-序列特异引物（PCR-SSP）法对58例壮族寻常型银屑病患者和102例健康壮族人的HLA-DQA1和DQB1座位进行基因分型，比较两组相应等位基因的频率。结果：HLA-DQB1*0303与壮族银屑病患者呈显著的正相关（OR=4.540，p=0.004），而HLA-DQA1*0501和HLA-DQB1*0301与壮族银屑病患者呈显著的负相关（OR=0.189，p=0.000；OR=0.367，p=0.018）。结论：以上3个HLA-DQ等位基因与广西壮族人寻常型银屑病的关系密切，其中HLA-DQB1*0303可能为该人群银屑病的易感因子，而HLA-DQA1*0501和HLA-DQB1*0301则可能对银屑病有抵抗作用。

关键词: 银屑病;HLA-DQ抗原;基因, DQB1

Abstract: Abstract Aim: To explore the possible roles of HLA-DQA1 and –DQB1 genes in the pathogenesis of psoriasis vulgaris in Zhuang people. Methods: Using polymerase chain reaction-sequence specific primer (PCR-SSP), HLA-DQA1 and –DQB1 loci were typed for 58 Zhuang patients with psoriasis vulgaris and 102 healthy Zhuang adults living in Guangxi. All allelic frequencies of HLA-DQA1 and -DQB1 were compared between the two groups. Results: Allele HLA-DQB1*0303 was found to be positively (OR=4.540，p=0.004), whereas HLA-DQA1*0501 and HLA-DQB1*0301 were negatively （OR=0.189，p=0.000；OR=0.367，p=0.018, respectively）related to psoriasis vulgaris in Zhuang population. Conclusions: These three HLA-DQ alleles are closely associated with the pathogenesis of psoriasis vulgaris in Zhuang ethnic group, where HLA-DQB1*0303 might work as a susceptible factor, while HLA-DQA1*0501 and HLA-DQB1*0301 might take a role of antigonist.