中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (1): 46-48.

• 论著 • 上一篇    下一篇

雌激素受体基因多态性与SLE的相关性研究

陈宏1,樊仪2,门剑龙3   

  1. 1. 天津市人民医院皮肤科
    2. 天津市长征医院皮肤科
    3. 天津医科大学总医院临床检验科
  • 收稿日期:2007-02-26 修回日期:2007-06-08 发布日期:2008-01-31
  • 通讯作者: 陈宏 E-mail:baixue20042006@126.com
  • 基金资助:
    天津市卫生局科技基金资助项目

  • Received:2007-02-26 Revised:2007-06-08 Published:2008-01-31
  • Contact: Hong CHEN E-mail:baixue20042006@126.com

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摘要： 目的 探讨雌激素受体与SLE的相关性。 方法 采用PCR/限制性片段长度多态性（PCR-RFLP）方法，检测82例SLE患者和正常人的雌激素受体多态性。结果 雌激素受体基因各基因型在正常人男性与正常人女性中的分布频率均较为接近，男、女性均以ppxx型、PpXx型最为常见；在男女性SLE患者中分布差异有统计学意义，男性患者中PpXx型的出现频率显著高于女性患者及正常人男性。女性患者中ER基因各型出现频率与正常人女性的差异无统计学意义。结论 男性患者PpXx基因型的携带率明显高于正常人男性对照，提示该基因型与男性SLE患者的易感性相关。

关键词: 红斑狼疮，系统性, 受体，雌激素, 基因

Abstract: Objective To investigate the relationship between estrogen receptor gene polymorphism and SLE. Methods The polymorphism of estrogen receptor gene was detected using PCR-restricted fragment length polymorphism in 82 patients with SLE and normal human controls. Results The distribution of estrogen receptor gene polymorphism was similar in the male and female controls, and, ppxx and PpXx were the most common genotypes. The distribution difference of estrogen receptor gene polymorphism was significant between the female and male SLE patients. The frequency of PpXx was significantly higher in the male patients than in the female patients and normal male controls （66.6% vs 21.1%, 66.6% vs 16.7%, respectively, both P < 0.05）. The distribution difference of estrogen receptor gene polymorphism was of no significant difference between the female patients and normal female controls. Conclusions The distribution difference of estrogen receptor gene polymorphism is significant between the male and female SLE patients, and the frequency of PpXx in male SLE patients is higher than that in female SLE patients and normal male controls, which hints the genotype may correlate with the susceptibility of male patients with SLE.