中华皮肤科杂志

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假性黑棘皮病患者血清瘦素及可溶性受体与胰岛素的测定

李久宏1, 毕桂姣1, 尚英彬1, 陈彤2, 邵伟2, 翟宁1, 宋芳吉1   

  1. 1. 中国医科大学附属第一医院皮肤科, 沈阳, 110001;
    2. 沈阳医学院附属奉天医院
  • 收稿日期:2006-08-21 出版日期:2007-07-15 发布日期:2007-07-15

Detection of serum leptin, soluble leptin receptor and insulin in patients with benign acanthosis nigricans

LI Jiu-hong1, BI Gui-jiao1, SHANG Ying-bin1, CHEN Tong2, SHAO Wei2, ZHAI Ning1, SONG Fang-ji1   

  1. Department of Dermatology, No.1 Hospital of China Medical University, Shenyang 110001, China
  • Received:2006-08-21 Online:2007-07-15 Published:2007-07-15

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摘要： 目的 探讨假性黑棘皮病患者血清瘦素及其受体与胰岛素之间的关系.方法 分别采用放射免疫分析法、酶联免疫吸附实验和葡萄糖氧化酶法检测25例假性黑棘皮病、20例单纯肥胖者瘦素、胰岛素、C肽可溶性受体与血糖水平,并与正常人对照组比较.结果 假性黑棘皮病患者和单纯肥胖者体质量、体质指数、脂肪百分比、腰臀围比明显高于正常人对照组,两组差异有统计学意义(P<0.01).假性黑棘皮病患者和单纯肥胖者胰岛素、C肽水平明显高于正常人对照组(P<0.01),胰岛素敏感指数低于正常人对照组(P<0.01);单纯肥胖者血糖水平和正常人对照组相比,差异无统计学意义(P>0.05);假性黑棘皮病患者与单纯肥胖者血清中瘦素水平和正常人对照组相比显著升高(P<0.01),可溶性瘦素受体水平显著降低(P<0.01).结论 假性黑棘皮病患者存在瘦素抵抗、高胰岛素血症和胰岛素抵抗,瘦素抵抗在假性黑棘皮病患者高胰岛素血症、胰岛素抵抗与肥胖中起一定的作用.

关键词: 棘皮症,黑, 胰岛素, 瘦素

Abstract: Objective To investigate the serum levels of leptin,soluble leptin receptor(sLR),and insulin as well as their relationship in benign acanthosis nigricans.Methods Twenty-five cases of benign acanthosis nigricans,20 cases of simple obesity and 20 healthy controls were detected for the concentrations of plasma leptin,insulin and C-peptide with radioimmunoassay,sLR with enzyme-linked immunoabsorbant assay(ELISA)and fasting blood glucose with glucose oxidase method.Results The body weight,body mass index,percentage of body fat(% BF),waist/hip ratio(WHR),serum insulin,C-peptide and leptin were all significantly higher,whereas the insulin sensitivity index and sLR were statistically lower,in patients with benign acanthosis nigricans or simple obesity than those in the normal controls(all P<0.01).No significant difference was found in fasting blood glucose between patients with benign acanthosis nigricans or simple obesity and the normal controls(P>0.05).Conclusion There is hyperinsulinaemia,insulin and leptin resistance in benign acanthosis nigricans,and leptin resistance may play a role in the occurrence of hyperinsulinaemia,insulin resistance and obesity in benign acanthosis nigricans.

Key words: Acanthosis nigricans, Insulin, Leptin