中华皮肤科杂志

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血管内皮生长因子、缺氧诱导因子1α及基质金属蛋白酶9在尖锐湿疣组织中的表达

尹光文1, 李敏1, 张守民2   

  1. 1. 郑州大学第一附属医院皮肤科;
    2. 河南省人民医院皮肤科
  • 收稿日期:2006-07-12 出版日期:2007-05-15 发布日期:2007-05-15

Expression of VEGF, HIF-1αand MMP-9 in condyloma acuminatum

YIN Guang-wen1, LI Min1, ZHANG Shou-min2   

  1. Department of Dermatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2006-07-12 Online:2007-05-15 Published:2007-05-15

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摘要： 目的 探讨尖锐湿疣(CA)组织中血管内皮生长因子(VEGF)、缺氧诱导因子(HIF)-1α、基质金属蛋白酶(MMP)-9的表达及意义。方法 采用免疫组化SP法检测35例CA组织中VEGF、HIF-1α、MMP-9的表达。结果 CA组织中VEGF、HIF-1α和MMP-9阳性表达率分别为100%(35/35)、94.28% (33/35)和100.00%(35/35),正常人对照组VEGF、HIF-1α及MMP-9阳性表达率分别为100.00%(15/ 15)、66.67%(10/15)和86.67%(13/15);CA组织中VEGF、HIF-1α和MMP-9阳性表达强度多存++～+++,正常人对照组多在-～++;两组VEGF和MMP-9阳性表达率差异均无统计学意义(P>0.05),但VEGF、HIF-1α和MMP-9的表达强度与正常人对照组比较差异均有统计学意义(P<0.01)。CA组织中VEGF与HIF-1α和MMP-9表达强度间存在正相关性。结论 CA组织中存在VEGF、HIF-1α和MMP-9过表达,VEGF、HIF-1α和MMP-9在促进CA血管生成中可能发挥作用。

关键词: 尖锐湿疣, 血管内皮生长因子类, 明胶酶B, 缺氧诱导因子1α

Abstract: Objective To explore the expression and significance of vascular endothelial growth factor(VEGF),hypoxia inducible factor(HIF-1α)and matrix metalloproteinase-9(MMP-9)in lesions of condyloma acuminatum(CA).Methods SP immunohistochemistry method was used to measure the expression of VEGF,HIF-1α and MMP-9 in 35 cases of CA and 15 normal skin controls.Results The positive rates ofVEGF,HIF-1αand MMP-9 were 100.00%(35/35),94.28%(33/35)and 100.00% (35/35)in CA tissues,while 100.00%(15/15),66.67%(10/15)and 86.67%(13/15)in the controls, and no significant difference was found in the positive rates of VEGF or MMP-9 between the two groups (both P>0.05).The expression intensity of VEGF,HIF-1α and MMP-9 was significantly increased in CA tissues than that in the controls(all P<0.01).The expression intensity of VEGF was positively correlated with that of HIF-1αand MMP-9(both P<0.01).Conclusions VEGF,HIF-1αand MMP-9 are over-expressed in CA tissues,and may play a role in promoting angiogenesis of CA.

Key words: Condylomata acuminata, Vascular endothelial growth factors, Gelatinase B, Hypoxia inducible factor 1α