中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (3): 155-157.

• 论著 • 上一篇    下一篇

磷酸化Stat3和磷酸化Akt及细胞周期蛋白D1在血管肉瘤中的表达

林能兴1, 连昕1, 占部和敬2, 古江增隆2, 涂亚庭1   

  1. 1. 华中科技大学同济医学院附属协和医院皮肤科, 武汉, 430022;
    2. 日本九州大学附属病院皮肤科
  • 收稿日期:2006-04-04 出版日期:2007-03-15 发布日期:2007-03-15

Expressions of phosphorylated Stat3, Akt and cyclin D1 in angiosarcoma

LIN Neng-xing1, LIAN Xin1, Kazunori Urabe2, Masutaka Furue2, TU Ya-ting1   

  1. Department of Dermatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2006-04-04 Online:2007-03-15 Published:2007-03-15

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摘要： 目的 探讨磷酸化细胞信号传导与转录活化因子3(Stat3)和磷酸化Akt及细胞周期蛋白D1在血管肉瘤中的表达.方法 采用免疫组化ABC的方法检测磷酸化Stat3(p-Stat3)和磷酸化Akt(pAkt)及细胞周期蛋白D1在21例血管肉瘤和15例毛细血管瘤石蜡包埋切片中的表达.结果 在21例血管肉瘤石蜡包埋切片中,有15例p-Stat3表达阳性,11例p-Akt表达阳性,16例细胞周期蛋白D1表达阳性;而在15例毛细血管瘤中仅有4例p-Stat3表达阳性,2例p-Akt表达阳性,4例细胞周期蛋白D1表达阳性,两组各阳性表达率分别经卡方检验发现,差异均有统计学意义(P<0.05).在血管肉瘤中,p-Stat3阳性表达与细胞周期蛋白D1的阳性表达有相关性(r=0.62,P=0.003),而p-Akt阳性表达与细胞周期蛋白D1的阳性表达无相关性(r=-0.09,P=0.700).结论 p-Stat3、p-Akt和细胞周期蛋白D1在血管肉瘤的形成机制中可能起一定的作用.

关键词: 尿道旁腺炎, 淋菌性, 尿道口, 血管肉瘤, 血管瘤,毛细管, 细胞周期蛋白D1, 蛋白激酶类

Abstract: Objective To investigate the expressions of phosphorylated signal transducer and activator of transcription-3 (p-Stat3),Akt (P-Akt)and cyclin D1 protein and their significance in angiosarcoma.Methods The expressions of p-Stat3, p-Akt and cyclin D1 protein were measured by ABC immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections obtained from 21 cases of angiosarcoma and 15 cases of capillary hemangioma.Results Of 21 cases of angiosarcoma, 15 were positive for p-Stat3, 16 for p-Akt and 11 for cyclin D1, whereas out of 15 cases of capillary hemangioma, 4 were positive for p-Stat3, 2 for p-Akt and 4 for cyclin D1, and there were significant differences in the positivily rates of the three proteins between the tw0o groups(X2=7.30, 5.78, 8.69, respectively, all P<0.05).In angiosarcoma, expression of cyclin D1 positively correlated with that of p-Stat3(r=0.62, P=0.003),but not with that of p-Akt(r=-0.09, P=0.700).Conclusion This study implies that the expression of p-Stat3, p-Akt and cyclin D1 may play a role in the oncogenesis of angiosarcoma.

Key words: Hemangiosarcoma, Hemangioma, capillary, Cyclin D1, Protein kinases