中华皮肤科杂志

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1999-2006年南京地区淋球菌对环丙沙星耐药现状的分析

其木格, 蒋法兴, 戴秀芹, 孙厚华, 叶顺章, 王千秋, 苏晓红   

  1. 中国医学科学院皮肤病研究所 南京 210042
  • 收稿日期:2007-05-23 出版日期:2007-12-15 发布日期:2007-12-15
  • 通讯作者: 苏晓红,email:suxhong@yahoo.com E-mail:suxhong@yahoo.com
  • 基金资助:
    国家教委出国人员启动基金项目(303051034)

Ciprofloxacin resistance in Neisseria gonorrhoeae in Nanjing City,1999-2006

QI Mu-ge, JIANG Fa-xing, DAI Xiu-qin, SUN Hou-hua, YE Shun-zhang, WANG Qian-qiu, SU Xiao-hong   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences Nanjing 210042, China
  • Received:2007-05-23 Online:2007-12-15 Published:2007-12-15

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摘要： 目的 了解南京地区1999-2006年淋球菌对环丙沙星的耐药现状.方法 对1999-2006年在南京地区性病门诊患者中分离到的1208株淋球菌,采用琼脂稀释法测定环丙沙星的最小抑菌浓度(MIC).结果 对环丙沙星耐药(MIC 1mg/L)的淋球菌率由1999年的83.93%(94/112)上升至2006年的98.99%(196/198),平均总耐药率为96.61%(1167/1208).其中环丙沙星高度耐药(MIC≥4mg/L)的淋球菌比率达71.61%(865/1208).结论 南京地区流行的淋球菌对环丙沙星的耐药情况极其严重.

关键词: 奈瑟球菌, 淋病, 环丙沙星, 抗药性, 细菌

Abstract: Objective To study ciprofloxacin resistance in Neisseria gonorrhoeae isolates in Nanjing City from 1999 to 2006.Methods Minimum inhibitory concentration(MIC)of ciprofloxacin was determined by agar dilution method in 1208 strains of N.gonorrhoeae isolated from outpatients in a STD clinic in Nanjing City.Results The prevalence of ciprofloxacin resistance increased from 83.93% in 1999 to 98.99% in 2006.Among these strains,71.61%(865/1208)were highly resistant(MIC≥4 mg/L)to ciprofloxacin.Conclusion In Nanjing City,ciprofloxacin resistance of N.gonorrhoeae is a significant public health issue.

Key words: Neisseria gonorrhoeae, Ciprofloxacin, Drug resistance,bacterial