中华皮肤科杂志

• 论著 • 上一篇    下一篇

骨桥蛋白及基质金属蛋白酶—9在恶性黑素瘤中的表达

黄长征, 杨井, 陶娟, 陈思远, 涂亚庭   

  1. 华中科技大学同济医学院附属协和医院皮肤科 武汉 430022
  • 收稿日期:2005-10-25 出版日期:2006-04-15 发布日期:2006-04-15

Expression of osteopontin and matrix metalloproteinase-9 in human malignant melanoma

HUANG Chang-zheng, YANG Jing, TAO Juan, CHEN Si-yuan, TU Ya-ting   

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2005-10-25 Online:2006-04-15 Published:2006-04-15

PDF (PC)

89

赞

摘要： 目的 探讨骨桥蛋白及基质金属蛋白酶-9(MMP-9)在人恶性黑素瘤中的表达及意义。方法 采用免疫组化SP法检测23例原发性恶性黑素瘤、17例转移性恶性黑素瘤及20例色素痣中骨桥蛋白和MMP-9的表达。结果 40例恶性黑素瘤中骨桥蛋白及MMP-9表达的阳性率分别为87.5%、75.0%;20例色素痣中的阳性表达率分别为15.0%、10.0%。骨桥蛋白及MMP-9在恶性黑素瘤中阳性表达率明显高于色素痣,差异具有统计学意义(P<0.05)。骨桥蛋白和MMP-9的表达与年龄、性别、发病部位、是否淋巴结转移等因素均无关(P>0.05)。40例恶性黑素瘤中,骨桥蛋白与MMP-9均表达29例,均不表达4例。结论 骨桥蛋白及MMP-9在人恶性黑素瘤中高表达,但与淋巴结转移无相关性。

关键词: 黑色素瘤, 明胶酶B, 骨桥蛋白

Abstract: Objective To investigate the expression of osteopontin and matrix metalloproteinase-9 (MMP9),and the relationship of osteopontin and MMP9 in malignant melanoma.Methods Expression of osteopontin and MMP9 was measured by immunohistochemical SP method in 23 patients with primary cutaneous malignant melanoma,17 patients with metastatic melanoma and 20 patients with pigmented nevus.Results Osteopontin and MMP9 were expressed respectively in 87.5% and 75.0% of 40 malignant melanoma specimens,15.0% and 10.0% of 20 pigmented nevus specimens.The expression of both osteopontin and MMP9 was significantly higher (both P<0.05) in malignant melanoma than in pigmented nevus.There was no correlation between the expression of osteopontin and MMP9,with age,sex,lymph node metastasis or location of lesions (P>0.05).Twenty-nine cases were positive for both osteopontin and MMP9,4 negative for either osteopontin or MMP9.Conclusion Both osteopontin and MMP9 were overexpressed in malignant melanoma,but neither was related to lymph node metastasis.

Key words: Melanoma, Gelatinase B, Osteopontin