中华皮肤科杂志

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层黏连蛋白、纤连蛋白在人毛囊生长周期中的表达

程波1, 潘佩英2, 姜晓勇3, 何勤4, 廖跃4   

  1. 1. 福建医科大学附属第一医院皮肤性病科 福州 350005;
    2. 贵阳市妇幼保健院病理科;
    3. 厦门中山医院皮肤性病科;
    4. 贵阳医学院附属医院皮肤性病科
  • 收稿日期:2005-03-28 出版日期:2006-02-15 发布日期:2006-02-15
  • 基金资助:
    中华医学会-欧莱雅中国人健康皮肤研究项目(200603060)

Expression of laminin and fibronectin in the growth cycle of human hair follicles

CHENG Bo1, PAN Pei-ying2, JIANG Xiao-yong3, HE Qin4, LIAO Yue4   

  1. Department of Dermatology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
  • Received:2005-03-28 Online:2006-02-15 Published:2006-02-15

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摘要： 目的 探讨层黏连蛋白(LM)、纤连蛋白(FN)在毛囊生长周期中的作用.方法 免疫组化S-P法检测LM、FN在毛囊生长期、退行期、休止期的表达.结果 ①生长期毛囊:LM均匀的表达于毛乳头处,在基底膜处呈明显的线状表达,外根鞘处表达也呈明显的阳性;FN均匀表达于毛乳头、基底膜、真皮鞘.②退行期毛囊:LM在毛乳头处少量表达,在基底膜处呈线状表达;FN在毛乳头和基底膜处表达均较生长期明显减少,但仍为阳性.③休止期毛囊:毛乳头浓缩成球点状,LM在毛乳头的表达为阴性,但在基底膜处仍然呈明显的线状表达,且较退行期更明显;FN在毛乳头、真皮鞘、基底膜处表达均为阴性.结论 LM、FN在毛囊的生长期、退行期及休止期的表达随毛囊生长周期而发生周期性变化,LM、FN可能参与毛囊生长周期的调节.

关键词: 毛囊, 层粘连蛋白, 纤连蛋白类

Abstract: Objectives To investigate the role of laminin (LM) and fibronectin (FN) in the growth cycle of human hair follicles.Methods The expression of LM and FN was detected by streptavidin-peroxidase (SP) staining.Results In the anagen phase,LM was expressed in dermal papilla,basement membrane and outer root sheath;FN was expressed in dermal papilla,basement membrane and connective tissue sheath.In the catagen phase,LM showed a lower expression in the dermal papilla and a linear expression in the basement membrane;the expression of FN in the dermal papilla and basement membrane was less intense than that in anagen phase,but was still positive.In the telogen phase,LM was only expressed in the basement membrane while FN was negative.Conclusion The difference between LM and FN expression in hair growth cycle indicates that LM and FN may play important roles in the regulation of human hair follicle growth cycl.

Key words: Hair follicle, Laminin, Fibronectins