中华皮肤科杂志

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补骨胶囊预防糖皮质激素所致系统性红斑狼疮患者骨质疏松或骨量减少的研究

陈秋霞1, 史建强1, 李常兴2, 周斌1, 覃冬梅3, 吴铁3, 吴志华1   

  1. 1. 广东医学院附属医院, 湛江 524000;
    2. 东莞市慢性病防治院;
    3. 广东医学院药理教研室
  • 收稿日期:2005-12-26 出版日期:2006-04-15 发布日期:2006-04-15
  • 基金资助:
    广东省医学科学技术研究课题(粤卫[2003] 189号)

Bugu capsules prevent glucocorticoid-induced osteoporosis or bone loss in SLE patients

CHEN Qiu-xia1, SHI Jian-qiang1, LI Chang-xing2, ZHOU Bin1, QIN mong-mei3, WU Tie3, WU Zhi-hua1   

  1. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
  • Received:2005-12-26 Online:2006-04-15 Published:2006-04-15

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摘要： 目的 探讨补骨胶囊预防系统性红斑狼疮(SLE)患者长期使用糖皮质激素治疗引起骨质疏松或骨量减少的临床疗效及作用机制.方法 66例SLE患者随机分为2组,A组34例患者采用糖皮质激素和补骨胶囊治疗,B组32例患者采用糖皮质激素治疗,30例健康者为对照组,分析30例同龄健康者和SLE患者治疗前后血钙、血磷、血清碱性磷酸酶、血甲状旁腺素、白细胞介素6(IL-6)水平,并进行三角区(Wards)等骨密度的测定.结果 B组和对照组IL-6、血钙和血甲状旁腺素的表达差异有统计学意义(P<0.01).A组有2例(5.88%)患者发生骨质疏松或骨量减少,而B组有9例(28.13%),组间差异有统计学意义(X2=4.38,P=0.0364).结论 补骨胶囊能防治SLE患者骨质疏松或骨量减少的发生,可能是通过恢复SLE患者体内IL-6、血钙和血甲状旁腺素的平衡起作用.

关键词: 红斑狼疮,系统性, 骨质疏松, 补骨胶囊

Abstract: Objective To investigate the prevention of glucocorticoid-induced osteoporosis or bone loss in systemic lupus erythematosus (SLE) patients by Bugu capsules.Methods Sixty-six patients with SLE were randomly divided into A and B groups:34 patients in Group A were treated by glucocorticoid and Bugu capsules,and 32 patients in Group B by glucocorticoid alone.All patients were measured for bone mineral density (BMD) in Wards triangle,and for related biochemical parameters such as serum calcium,phosphonium,alkaline phosphatase,parathyroid hormone (PTH) and interleukin-6 (IL-6) before and after the treatment.As the control group,thirty healthy subjects were measured for the above parameters.Results There was significant difference in the serum level of IL-6,calcium and PTH between the Group B and control group (P<0.01).The occurrence rate of osteoporosis or bone loss in group A was significant lower than that in group B [2/34 (5.88%) vs 9/32 (28.13%),P=0.0364] .Conclusion Bugu capsules can prevent glucocorticoid-induced osteoporosis or bone loss in SLE patients,possibly by restoring the balance among serum IL-6,calcium and PTH.

Key words: Lupus erythematosus,systemic, Osteoporosis, Bugu capsules