中华皮肤科杂志

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皮肤淀粉样变性皮损中T/B细胞的检测

许金国, 卢宪梅, 赵天恩   

  1. 山东省皮肤病与性病防治研究所, 济南 250022
  • 收稿日期:2006-01-05 出版日期:2006-04-15 发布日期:2006-04-15

Detection of T and B lymphocytes in lesions of primary cutaneous amyloidosis

XU Jin-guo, LU Xian-mei, ZHAO Tian-en   

  1. Shandong Provincial Institute Of Dermatology and Venereology, Jinan 250022, China
  • Received:2006-01-05 Online:2006-04-15 Published:2006-04-15

摘要: 目的 探讨原发性皮肤淀粉样变性皮损中T/B细胞变化的差异及其意义.方法 60例患者局部病变皮损标本、29例正常人皮肤标本,分别进行CD3、CD4、CD8、CD20免疫组化染色.结果 与正常人对照组比较,皮肤淀粉样变性皮损中,淋巴细胞总数、CD3+T细胞、CD8+T细胞的均数增高(P<0.05),CD4+T细胞均数无明显增高(P>0.05),CD4+/CD8+T细胞比值下降(P<0.05),CD20+B细胞均数增高(P<0.05).T淋巴细胞、B淋巴细胞在原发性皮肤淀粉样变性苔藓样、斑疹型或双相型三种分型病变间相互比较,差异无统计学意义(P>0.05).结论 原发性皮肤淀粉样变性局部皮损存在有T/B淋巴细胞的异常表达,但三种病变类型间病变机制的免疫学异常无区别.

关键词: 淀粉样变性, B淋巴细胞, T淋巴细胞

Abstract: Objective To investigate the profile,and to assess the significance of T and B lymphocytes in the lesional skin of primary cutaneous amyloidosis.Methods Immunohistochemistry was used to detect the CD3,CD4,CD8 and CD20 markers on T and B lymphocytes in lesions of 60 patients with primary cutaneous amyloidosis,and in the skin of 29 normal controls.Results Compared to skin obtained from control population,the total number of lymphocytes,the mean number of CD3+ T lymphocytes,CD8+ T lymphocytes and CD20+ B lymphocytes,were all significantly elevated (all P<0.05),while the ratio of CD4+ T lymphocytes to CD8+ T lymphocytes was significantly decreased (P<0.05) in the lesional skin of primary cutaneous amyloidosis.There was no significant difference (P>0.05) in the mean number of CD4+ T lymphocytes in skin obtained from the control population and lesional skin obtained from patients.There was no significant difference among the lesions of lichen amyloidosis,macular amyloidosis and biphasic amyloidosis in the mean number of T lymphocytes or that of B lymphocytes (P>0.05).Conclusion There is abnormal expression of T and B lymphocytes in the local lesions of primary cutaneous amyloidosis,but there is no difference in the T and B lymphocyte profile among the three clinical types of primary cutaneous amyloidosis.

Key words: Amyloidosis, T-lymphocytes, B-lymphocytes