中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (1): 26-28.

• 论著 • 上一篇    下一篇

0.05%地奈德乳膏治疗湿疹的多中心随机双盲、对照研究

孙建方1, 郑志忠2, 顾军3, 曾学思1, 付雯雯2, 毕新岭3   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042;
    2. 复旦大学附属华山医院;
    3. 第二军医大学长海医院
  • 收稿日期:2005-01-25 发布日期:2006-01-15

0.05% desonide cream for the treatment of patients with eczema:a ramdomized,double-blind,multicenter study

SUN Jian-fang1, ZHENG Zhi-zhong2, GU Jun3, ZENG Xue-si1, FU Wen-wen2, BI Xin-ling3   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2005-01-25 Published:2006-01-15

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摘要： 目的 了解0.05%地奈德乳膏治疗湿疹的临床疗效及安全性.方法 采用多中心、随机双盲、安慰剂对照法,试验组及对照组患者分别外用0.05%地奈德乳膏及地奈德基质,每日2次,共治疗3周.对红斑、糜烂、浸润、丘疹、渗出/结痂、瘙痒及皮损面积的总积分进行评价.结果 治疗结束时,试验组的临床总有效率为80.8%,对照组为41.1%.两组间的疗效差异有统计学意义(P<0.0001);试验组未见与用药相关的不良反应.结论 0.05%的地奈德乳膏治疗湿疹临床疗效可靠,安全性高.

关键词: 湿疹, 随机对照试验, 地奈德

Abstract: Objective To evaluate the efficacy and safety of 0.05% desonide cream in the treatment of patients with eczema.Methods A randomized,double-blind,multicenter,vehicle-controlled study was conducted.The patients of the study and control groups applied 0.05% desonide cream and vehicle respectively,twice daily for 3 consecutive weeks.The efficacy was determined by measuring the total scores of erythema,erosion,infiltration,papule,exudation/crust,pruritus and the extent of lesions.Results At the end of the 3 weeks study,the total clinical effective rate was 80.8% in the study group,compared to 41.1% in the control group,with a significant difference between the two groups (P<0.0001).No adverse effect was found related to the drug in the study group.Conclusion 0.05% desonide cream is effective and safe for patients with eczema.

Key words: Eczema, Randomized controlled trials, Desonide