中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (8): 498-500.

• 论著 • 上一篇    下一篇

婴儿慢性皮肤黏膜念珠菌病一例及实验研究

张雅洁1, 廉翠红2, 刘维达3   

  1. 1. 暨南大学医学院第二附属医院深圳市人民医院 深圳市 518020;
    2. 深圳市第二人民医院;
    3. 中国医学科学院、中国协和医科大学皮肤病研究所
  • 收稿日期:2005-01-12 出版日期:2005-08-15 发布日期:2005-08-15

Infantile Chronic Mucocutaneous Candidiasis:A Case Report and Laboratory Study

ZHANG Ya-jie1, LIAN Cui-hong2, LIU Wei-da3   

  1. Derpartment of Dermatology, Shenzhen People's Hospital, Shenzhen 518020, China
  • Received:2005-01-12 Online:2005-08-15 Published:2005-08-15

PDF

146

赞

摘要： 目的 报道1例营养不良和免疫低下所引起的婴儿慢性皮肤黏膜念珠菌病.方法 取患儿不同部位皮损标本直接镜检、真菌培养、相关菌学鉴定试验及分子生物学实验,确定致病菌种及药物敏感范围.结果 患儿为5月女婴,大头貌,3个月前,无明显诱因在头、双耳廓、鼻孔、口腔、颈部、双腋下、臀部出现红斑、糜烂,表面结痂,伴瘙痒,头发、指趾甲生长不良.皮损刮取物进行真菌镜检和培养,发现臀部有白念珠菌生长,头屑有光滑念珠菌生长.淋巴细胞免疫表型分析CD16+566.5%,血清IgG6.74g/L,IgA321mg/L,血清白蛋白18g/L,均降低.提示患儿为低蛋白营养不良并存在免疫低下.结论 结合喂养史、临床和实验室检查诊断为继发性营养不良所致婴儿慢性皮肤黏膜念珠菌病.

关键词: 营养障碍, 念珠菌病,慢性粘膜皮肤

Abstract: Objective To investigate the clinical and laboratory profiles of a case of infantile chronic mucocutaneous candidiasis due to malnutrition.Methods Skin specimens were collected and examined by KOH preparation,fungus culture,biochemical tests and molecular biological study.The pathogenic strain and antimicrobial susceptibility were defined.Results A 5 month-old-girl was presented with big head,and erythema,erosion and crust on her head,auricles,nostrils,oral cavity,neck and buttocks,and itching,for 1 month.Dystrophic hair and nails were observed.Candida albicans was isolated from specimens of the buttocks and Candida glabrata from the scalp.The abnormalities,CD16+ (56 6.5%),serum IgG (6.74 g/L),IgA (0.321 g/L),and albumin (18 g/L) were found with flow cytometry and immunoassays.Conclusion The patient is diagnosed as infantile chronic mucocutaneous candidiasis,who is immunocompromised due to protein malnutrition.

Key words: Candidiasis,chronic mucocutaneous, Nutrition disorders