中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (5): 303-305.

• 论著 • 上一篇    下一篇

女贞子等对人头皮毛囊体外培养影响的研究

孙宇1, 杨淑霞1, 涂平1, 宋继权2, 丁杨峰3   

  1. 1. 北京大学第一附属医院皮肤科, 100034;
    2. 武汉大学中南医院皮肤科;
    3. 上海市皮肤性病医院
  • 收稿日期:2004-05-16 出版日期:2005-05-15 发布日期:2005-05-15

Effect of Chinese Medicinal Herbs on Human Scalp Hair Growth in Vitro

SUN Yu1, YANG Shu-xia1, TU Ping1, SONG Ji-quan2, DING Yang-feng3   

  1. Department of Dermatology, Peking University First Hospital, Beijing 100034, China
  • Received:2004-05-16 Online:2005-05-15 Published:2005-05-15

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摘要： 目的 研究中药对体外培养人头皮毛囊生长的影响。方法 观察不同浓度的野山楂、女贞子、猪苓、白芨提取物混合剂以及人参总皂甙对体外培养人头皮毛发生长的影响。结果 野山楂、女贞子、猪苓、白芨提取物混合剂低剂量组(1.28μg/mL和6.4μg/mL)在培养初期和末期加速毛发生长,32μg/mL在培养末期加速毛发生长。低剂量组(1.28μg/mL,6.4μg/mL,32μg/mL)可延长毛发的生长时间,尤以1.28μg/mL和6.4μg/mL组的延长作用更强;中剂量组(160μg/mL和800μg/mL)仅在培养初期加速毛发生长,而对毛发生长时间的影响不明显;高剂量组(4mg/mL和20mg/mL)在整个生长周期抑制毛发生长,同时缩短毛发生长时间。人参总皂甙高剂量组(40μg/mL和200μg/mL)抑制毛发的生长,缩短毛发的生长时间,且浓度越高,抑制作用越强,缩短作用越明显。结论 低剂量的野山楂、女贞子、猪苓、白芨提取物混合剂对体外培养的人头皮毛囊生长有促进作用。

关键词: 毛囊, 器官培养, 中药

Abstract: Objective To study the effect of Chinese herbs on human scalp hair growth in vitro. Methods Organ culture of human scalp hair follicles was used to study the effects of extracts of Crataegus cuneata, Ligustrum lucidum, Polyporus umbelatus and Bletilla striata mixture and ginseng saponin on hair growth. Results Low doses of mixture extracts(1.28 μg/mL and 6.4 μg/mL) markedly enhanced the hair growth and lengthened the period of hair growth, while high doses of mixture extracts(4 mg/mL and 20 mg/mL) sharply inhibited hair growth and shortened the period of hair growth. High doses of ginseng saponin (40 μg/mL and 200 μg/mL) also had an inhibiting effect on hair growth. Conclusion This observation suggests that extracts of Crataegus cuneata, Ligustrum lucidum, Polyporus umbelatus and Bletilla striata mixture can promote hair growth in vitro.

Key words: Hair follicle, Organ culture, Herb, medicinal