中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (1): 3-4.

• 论著 • 上一篇    下一篇

系统性红斑狼疮与HLA-A等位基因相关性的研究

许绍斌, 陶玉芬, 初正韬, 黄小琴, 班贵宏, 俞建昆, 褚嘉祐   

  1. 中国医学科学院、中国协和医科大学医学生物学研究所医学遗传室, 昆明650118
  • 收稿日期:2004-01-17 出版日期:2005-01-15 发布日期:2005-01-15
  • 通讯作者: 褚嘉祐,E-mail:chujy@public.km.yn.cn E-mail:chujy@public.km.yn.cn
  • 基金资助:
    国家863基金资助项目(2001AA227041);云南省应用基础基金资助项目(2000C0009Z)

Association of HLA-A Alleles with Systemic Lupus Erythematosus

XU Shao-bin, TAO Yu-fen, CHU Zheng-tao, HUANG Xiao-qin, BAN Gui-hong, YU Jian-kun, CHU Jia-you   

  1. Department of Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China
  • Received:2004-01-17 Online:2005-01-15 Published:2005-01-15

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摘要： 目的 探讨系统性红斑狼疮(SLE)的发生与HLA-A等位基因间的关系。方法 应用聚合酶链反应-序列特异性引物(PCR-SSP)的方法,对106例SLE患者和122例健康人进行HLA-A等位基因的检测。结果 共发现19种等位基因,SLE患者中检出18种,对照组中检出15种。其中A*11等位基因与SLE呈强正相关(RR=2.4380,EF=0.1502,χ2=12.2440,P=0.0005,Pc=0.0095);A*01和A*24等位基因尽管P值均<0.05(分别为0.0498和0.0124),但Pc值都>0.05(分别为0.9462和0.2356)。结论 A*11可能是云南汉族SLE的易感等位基因或与易感基因相连锁。

关键词: 红斑狼疮,系统性, 基因,MHCI类, 聚合酶链反应-序列特异性引物

Abstract: Objective To explore the potential association of HLA-A alleles and genetic susceptibility with systemic lupus erythematosus (SLE). Methods Polymerase chain reaction-sequence specific primer (PCR-SSP) was used to analyze the distribution of HLA-A alleles among 106 patients with systemic lupus erythematosus and 122 healthy persons. Results Nineteen out of twenty-four kinds of HLA-A alleles were found from the specimens, including 18 kinds in SLE specimens, and 15 kinds in control specimens. Among them, HLA-A*11 allele was positively associated with SLE (RR=2.4380, EF=0.1502, χ2=12.2440, P=0.0005, Pc=0.0095). For A*01 and A*24, although the P values were less than 0.05, the Pc values were more than 0.05 (0.9462 or 0.2356, respectively). Conclusions The results indicate that HLA-A*11 may be the susceptible allele or may be closely linked with the susceptible genes in Chinese SLE patients.

Key words: Lupus erythematosus, systemic, Genes, MHC class I, Polymerase chain reaction-sequence specific primer