中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (9): 499-500.

• 论著 • 上一篇    下一篇

梅毒与系统性红斑狼疮患者抗心磷脂抗体的比较研究

王雅坤, 赵玉铭, 陈洪铎, 郭英军   

  1. 中国医科大学附属第一医院皮肤科, 沈阳110001
  • 收稿日期:2002-10-08 出版日期:2003-09-15 发布日期:2003-09-15

A Comparative Study of Anticardiolipin Antibodies in Syphilis and SLE

WANG Ya-kun, ZHAO Yu-ming, CHEN Hong-duo, GUO Ying-jun   

  1. Department of Dermatology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2002-10-08 Online:2003-09-15 Published:2003-09-15

摘要: 目的 对梅毒和系统性红斑狼疮(SLE)患者血清中抗心磷脂(ACL)抗体的反应强度以及类型进行比较研究。方法 应用ELISA法对99例梅毒和75例SLE患者的血清中ACL抗体的反应强度以及ACL抗体的IgG与IgM类型进行检测。结果 SLE和梅毒患者血清中IgG型ACL抗体阳性率分别为48.00%和40.40%;梅毒的阳性血清反应强度高于SLE患者(P<0.001);IgM型ACL抗体的阳性率在SLE和梅毒患者中分别为18.67%和61.62%,梅毒的ACL抗体阳性率显著高于SLE患者(P<0.001),且梅毒患者IgM型ACL抗体阳性血清反应强度高于SLE患者(P<0.005)。结论 这种ACL抗体IgG、IgM阳性率与反应强度的差异,反映了SLE患者和梅毒患者产生ACL抗体的机理与功能有所不同。

关键词: 抗体,抗心脂, 梅毒, 红斑狼疮,系统性

Abstract: Objective To compare the intensity and isotype of anticardiolipin(ACL)antibodies in the sera from patients with syphilis and SLE.Methods IgG and IgM type of ACL antibodies were examined by ELISA in 99 syphilis patients and 75SLE patients.Results Although similar positive percentage of IgG ACL antibodies was shown in syphilis and SLE patients,stronger absorbance(A value)was seen in syphilis patients(P<0.001).Higher positivity rate of IgM ACL antibodies was shown in syphilis than in SLE(61.62%vs18.67%)(P<0.001),and that with stronger intensity of reaction(P<0.05).Conclusion The different reaction intensity and the different positivity rates of different isotypes might be a reflection of the difference in the mechanism of antibody production and functional activities of these antibodies in SLE and syphilis.

Key words: Antibodies,anticardiolipin, Syphilis, Lupus erythematosus,systemic