中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (6): 313-315.

• 论著 • 上一篇    下一篇

不同浓度过氧苯甲酰凝胶治疗寻常痤疮

王爱平, 涂平, 季素珍, 吴艳, 沈悦, 朱学骏   

  1. 北京大学第一医院皮肤性病科 100034
  • 收稿日期:2002-04-22 出版日期:2003-06-15 发布日期:2003-06-15

Clinical Efficacy of Benzoyl Peroxide Gel with Different Concentrations in Acne Vulgaris

WANG Ai-ping, TU Ping, JI Su-zhen, WU Yan, SHEN Yue, ZHU Xue-Jun   

  1. Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, China
  • Received:2002-04-22 Online:2003-06-15 Published:2003-06-15

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摘要： 目的 评价不同浓度过氧苯甲酰凝胶治疗寻常痤疮的疗效和安全性,对5%过氧苯甲酰凝胶国内外同类产品进行比较。方法 采用开放对照临床试验,每天外用2次,疗程6周,在治疗的第2、4、6周进行随访。结果 不同浓度的过氧苯甲酰凝胶对炎性损害有效,随疗程延长、药物浓度增加,总体疗效明显增高,以5%和10%浓度为最佳。不良反应发生率也随药物浓度增加而增高,主要表现为用药局部短暂轻度皮肤刺激感,耐受性好。5%过氧苯甲酰凝胶与国内同类产品比较疗效相似,不良反应发生率低。结论 不同浓度过氧苯甲酰凝胶是治疗寻常痤疮有效安全的药物,以5%和10%浓度为最佳。

关键词: 过氧化苯甲酰凝胶, 寻常痤疮, 开放、对照临床试验

Abstract: Objective To assess the clinical efficacy and safety of benzoyl peroxide gel(BPG)with different concentrations in the treatment of acne vulgaris,and to compare the quality between the domestic products with imported products.Methods The study was an open-controlled clinical trial.The patients were divided into4groups:imported 2.5%,5%,10% gel and domestic 5% gel.All preparations were applied twice daily for6weeks.Study visits took place at baseline and week 2,4 and 6.Results Different concentrations of benzoyl peroxide gel were effective for inflammatory lesions.The longer the course of treatment and the higher the drug concentration were,the better global clinical efficacy was,and the optimum concentration was 5% or 10%.In addition,the higher the drug concentration was,the higher adverse reaction rate was.Transient and mild local skin irritation occurred but was well tolerated by the patients.The imported benzoyl peroxide 5% gel was as effective as domestic benzoyl peroxide 5% gel,but the adverse reaction rate was less than the latter.Conclusion Different concentrations of benzoyl peroxide gel are all effective and safe in the treatment of acne vulgaris,with the optimum concertration is 5% or 10%.

Key words: Benzoyl peroxide gel, Acne vulgaris, Open-controlled clinical trial