中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (6): 303-305.

• 论著 •    下一篇

淋巴瘤样丘疹病继发蕈样肉芽肿:共同T细胞克隆增生一例报告

王平1, 邱丙森2, 高红阳3, 陈明华2, 单易非3   

  1. 1. 东南大学附属中大医院皮肤科 南京 210009;
    2. 复旦大学医学院附属华山医院皮肤科;
    3. 复旦大学医学院分子生物学教研室
  • 收稿日期:2002-04-22 出版日期:2003-06-15 发布日期:2003-06-15

A Case Report of Lymphomatoid Papulosis Followed By Mycosis Fungoides:Derived from a Common T Cell Clone

WANG Ping1, QIU Bing-sen2, GAO Hong-yang3, CHEN Ming-hua2, SHAN Yi-fei3   

  1. Department of Dermatology, Zhongda Hospital of Southeast University, Nanjing 210009, China
  • Received:2002-04-22 Online:2003-06-15 Published:2003-06-15

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摘要： 目的 报道一例淋巴瘤样丘疹病(LyP)继发蕈样肉芽肿(MF),随访27年,并检测其克隆性是否与疾病相关。方法 比较不同时期的皮肤组织病理和免疫表型特点,同时应用聚合酶链反应(PCR)和Southern印迹杂交法,检测皮损组织和外周血标本的T细胞受体基因重排。结果 此例在不同时期各具临床病理学特征,增生的淋巴细胞为成熟的Th细胞,且示共同T细胞克隆。结论 LyP继发MF示相同T细胞克隆,克隆性T细胞与疾病的生物行为无关。

关键词: 淋巴瘤样丘疹病, 淋巴瘤, T细胞, T淋巴细胞, 免疫表型分型

Abstract: Objective To report a case of lymphomatoid papulosis(LyP)followed by mycosis fun-goides(MF)during his 27 years course and determine whether these diseases are clonally related.Methods Characteristics of clinicopathology and immunophenotype of skin tissues of different phases of the patients were compared.Simultaneously,clonal T-cell receptor gene rearrangement of skin lesion tissues and blood specimens were detected by means of polymerase chain reaction and Southern blot analysis.Results A distinctc clinisal and pathological feature was shown in this case df LyP flowed by MF.The proliferating lymphocytes in LyP and MF were mature T helper lymphocytes,and with same T-cell clone.Conclusion LyP folloewd by MF displays a same T-cell clone.The clonal T-cell is irrelevant to the biological behavior of these diseases.

Key words: Lymphomatoid papulosis, Lymphoma,T-cell, T-lymphocytes, Immunophenotyping