中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (5): 270-272.

• 论著 • 上一篇    下一篇

体检和性罪错人群宫颈中解脲脲原体的检测

任翊1, 孙丹2, 赵春惠2, 朱学骏1   

  1. 1. 北京大学第一医院皮肤性病科, 100034;
    2. 北京佑安医院北京市性病防治所
  • 收稿日期:2002-04-25 出版日期:2003-05-15 发布日期:2003-05-15

The Detection of Ureaplasma urealyticum in Cervix of Gynecologic Check-up Population and Female Sex Workers and Its Biovars and Serotypes

REN Yi1, SUN Dan2, ZHAO Chun-hui2, ZHU Xue-jun1   

  1. Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, China
  • Received:2002-04-25 Online:2003-05-15 Published:2003-05-15

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摘要： 目的 了解解脲脲原体(Uu)在体检人群和性罪错人群的宫颈检出情况及生物分群分型。方法 用支原体液体选择培养基筛查妇科体检人群和性罪错人群,对阳性标本再用PCR法进行生物分群分型。结果 性罪错人群共筛查了卖淫妇女98例,体检人群共筛查了体检妇女164例。性罪错组中Uu液体培养阳性89例(90.8%),其中生物1群64例(71.9%),1+2群7例(7.9%),2群18例(20.2%);71例生物1群阳性的标本中,以血清1、3、6、14型两个或两个以上的同时感染为混合感染,以血清1、3、6、14型的单独感染为单纯感染。性罪错组中混合感染17例(23.9%),单纯感染54例(76.1%);54例单纯感染中血清1型17例(31.5%),3型22例(40.7%),6型15例(27.8%)。体检人群组中Uu液体培养阳性104例(63.4%),其中生物1群97例(93.3%),2群7例(6.7%);97例生物1群阳性的标本中,混合感染11例(11.3%),单纯感染86例(88.7%),86例单纯感染中血清1型22例(25.6%),3型37例(43.0%),6型27例(31.4%)。结论 Uu在性罪错人群中的检出率高于体检人群(P<0.01),在Uu培养阳性的标本中,生物2群的检出率性罪错人群高于体检人群(P<0.01),在Uu生物1群阳性的标本中,混合感染的检出率性罪错人群高于体检人群(P<0.05),而生物1群中各血清型的单纯感染两组间没有统计学差异。

关键词: 尿素支原体,尿素分解, 血清分型

Abstract: Objective To investigate Ureaplasma urealyticum in cervical specimens of gynecologic check-up population and female sex workers(FSW)and its biovars and serotypes.Methods The gynecologic check-up patients and female sex workers were screened using Uu liquid selective medium.The positive cases were then divided into biovars and serotypes by the means of PCR.Results Ninety-eight FSW and 164 gynecologic check-up patients were investigated.In the FSW group,89 cases(90.8%)were positive in culture,including biovar 164 cases(71.9%),biovar 1+27 cases(7.9%),biovar 218 cases(20.2%).In 71 biovar 1 positive cases,biovar 1+2 and coinfection of serotypes of biovar1were defined as mixed infection.Infection with single serotype of biovar 1 was defined as simple infection.So in 71 biovar1positive cases of FSW group,there were 17 mixed infections(23.9%)and 54 simple infections(76.1%).Simple infections were then subdivided into serotypes,including serotype 117 cases(31.5%),serotype 322 cases(40.7%),and serotype 615 cases(27.8%).In gynecologic check-up group,104 cases(63.4%)were culture positive,including biovar 197 cases(93.3%),biovar 27 cases(6.7%).In 97 biovar 1 positive cases,there were 11 mixed infections(11.3%)and 86 simple infections(88.7%).In 86 simple infections,there were serotype 122 cases(25.6%),serotype 337 cases(43.0%),and serotype 627 cases(31.4%).Conclusions The positive rate of Uu in FSW is higher than that of gynecologic check-up population(P<0.01).The positive rate of Uu biovar 2 in FSW is higher than that of control group(P<0.01).The mixed infection in sex workers is higher than that of gynecologic check-up population(P<0.05).There is no statistic difference in simple infection caused by serotypes of biovar1between the two group.

Key words: Ureaplasma urealyticum, Serotyping