中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (2): 79-81.

• 论著 • 上一篇    下一篇

斑秃患者血浆和皮损中降钙素基因相关肽、血管活性肠肽的研究

肖风丽1, 高顺强1, 姚贵申2, 高艳青1, 林元珠1   

  1. 1. 河北医科大学第四医院皮肤科;
    2. 邯郸医学高等专科学校附属医院皮肤科
  • 收稿日期:2002-01-28 出版日期:2003-02-15 发布日期:2003-02-15
  • 基金资助:
    河北省科技厅科技攻关项目资助(00276190D)

Calcitonin Gene-related peptides and Vasoactive Intestinal Peptide in Plasma and Lesion of Patients with Alopecia Areata

XIAO Feng-li1, GAO Shun-qiang1, YAO Gui-shen2, GAO Yan-qing1, LIN Yuan-zhu1   

  1. Department of Dermatology, Fouth Hospital, Hebei Medical University, Shijiazhuang 050011, China
  • Received:2002-01-28 Online:2003-02-15 Published:2003-02-15

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摘要： 目的 探讨降钙素基因相关肽(CGRP)和血管活性肠肽(VIP)在斑秃发病中的作用。方法 利用放射免疫分析法检测30例斑秃患者和20例正常人血浆中的CGRP和VIP水平,利用免疫组化方法检测21例斑秃患者皮损和16例正常人头皮中的CGRP和VIP表达情况。结果 ①斑秃活动期患者血浆中的CGRP水平为(142.63±67.95)pg/mL,低于稳定期(197.33±67.15)pg/mL和正常人(188.40±72.95)pg/mL,差异均有显著性。②斑秃活动期血浆中的VIP水平为(105.94±55.42)pg/mL,低于斑秃稳定期(156.86±47.37)pg/mL和正常人(176.44±84.70)pg/mL,差异均有显著性。③CGRP和VIP在斑秃皮损及其周围的表达明显低于正常人,差异有显著性。结论 CGRP和VIP在斑秃发病中起一定的作用。

关键词: 斑秃, 降钙素基因相关肽, 血管活性肠肽

Abstract: Objective To study the role of calcitonin gene-related peptide(CGRP)and vasoactive intestinal peptide(VIP)in the pathogenesis of alopecia areata(AA).Methods Radioimmunoassay(RIA)was used to measure the levels of CGRP and VIP in plasma from 30 patients with AA and 20 normal controls.Immunohistochemistry was employed to detect the expression of CGRP and VIP in lesions of 21 patients with AA and16normal scalps. Results ①The plasma levels of CGRP in progressing stage of AA(142.63±67.95pg/mL)were significantly lower than those in stable stage of AA(197.33±67.15pg/mL)and in normal controls(188.40±72.95pg/mL).②The plasma levels of VIP in progressing stage of AA(105.94±55.42pg/mL)were significantly lower than those in stable stage of AA(156.86±47.37pg/mL)and in normal controls(176.44±84.70pg/mL).③The expression of CGRP and VIP was significanly decreased in lesions of AA than that in normal scalps.Conclusion These findings indicate that CGRP and VIP may play a role in the pathogenesis of alopecia areata.

Key words: Alopecia areata, Calcitonin gene-related peptide, Vasoactive intestinal peptide