中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (10): 562-564.

• 论著 • 上一篇    下一篇

结合珠蛋白表型与五种皮肤病的关系

张亚芹, 李萍, 高兴华, 王雅坤, 赵玉铭, 何春涤, 陈洪铎   

  1. 中国医科大学附属第一医院皮肤科 沈阳 110001
  • 收稿日期:2012-10-10 出版日期:2003-10-15 发布日期:2003-10-15
  • 基金资助:
    国家自然科学基金资助项目(3997068)

Distribution of Haptoglobin Phenotypes in Five Skin Diseases and Their Clinical Significance

ZHANG Ya-qin, LI Ping, Gao Xing-hua, WANG Ya-kun, ZHAO Yu-ming, HE Chun-di, CHEN Hong-duo   

  1. Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2012-10-10 Online:2003-10-15 Published:2003-10-15

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摘要： 目的 研究结合珠蛋白表型在5种皮肤病中的分布及其意义。方法 通过变性的不连续聚丙烯酰胺凝胶电泳(12% SDS-PAGE),硝酸银染色确定结合珠蛋白表型。结果 正常汉族人结合珠蛋白表型Hp1-1、Hp2-1 Hp2-2型分别为9.9%、46.9%和43.2%,与正常人对照相比,结合珠蛋白Hp2-2型的频率在系统性红斑狼疮患者中明显增高(59.3%),且有容易伴发肾脏损害的倾向;2-1型在银屑病患者中降低(30.9%);1-1型在湿疹患者中增高(27.4%),且有不容易伴发渗出的倾向,而结合珠蛋白表型在二期梅毒和尖锐湿疣患者中的分布无统计学意义。结论 结合珠蛋白表型可能与这些皮肤病的发病和临床表现有关系。

关键词: 触珠蛋白类, 表型, 皮肤疾病

Abstract: Objective To investigate the distributions of haptoglobin (Hp) phenotypes and their clinical significance in five skin diseases. Methods Haptoglobin phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in a discontinuous buffer system, and then confirmed by staining with silver nitrate. Results The distribution of Hp1-1, Hp2-1, Hp 2-2 of Han ethnic group was 9.9 percent, 46.9 percent, 43.2 percent, respectively. Compared with normal controls, the frequency of Hp2-2 in SLE group (59.3%) was markedly high, especially in those with kidney damage, that of Hp2-1 in psoriasis(30.9%) was low, and that of Hp1-1 in eczema was high, especially in those without exudation (27.4%). There was no statistical significance for the distributions of Hp phenotypes in secondary syphilis and condyloma acuminatum. Conclusion Hp phenotypes might be associated with the pathogensis and some clinical manifestations in SLE, psoriasis of eczema.

Key words: Haptoglobins, Phenotype, Skin diseases