中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (1): 23-24.

• 论著 • 上一篇    下一篇

广西壮族系统性红斑狼疮与HLA-DRB1等位基因相关性研究

梁伶, 郑文军   

  1. 广西医科大学第一附属医院皮肤科, 南宁530021
  • 收稿日期:2002-01-22 出版日期:2003-01-15 发布日期:2003-01-15
  • 基金资助:
    广西科学基金(9912041)

Association of HLA-DRB1 Alleles and Systematic Lupus Erythematosus of the Zhuang Nationality in Guangxi Province

LIANG Ling, ZHENG Wen-jun   

  1. Department of Dermatology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2002-01-22 Online:2003-01-15 Published:2003-01-15

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摘要： 目的 探讨广西壮族系统性红斑狼疮(SLE)与HLA-DRB1基因的相关性。方法 用聚合酶链反应-序列特异性引物(PCR-SSP)方法,对52例SLE壮族患者和70例壮族健康人的HLA-DRB1基因进行研究。结果 SLE患者HLA-DRB1*1401及DRB1*16两个等位基因的频率低于正常对照组(RR=0.28,χ2=5.00,P=0.02及RR=0.39,χ2=3.95,P=0.05),患者组和对照组均未检出HLA-DRB1*08、DRB1*11和DRB1*13等位基因。结论 提示HLA-DRB1*1401及DRB1*16等位基因可能是广西壮族人SLE的保护基因,未发现易感基因。

关键词: 红斑狼疮,系统性, HLA-DR抗原

Abstract: Objective To study the relationship between HLA-DRB1 alleles and the systematic lupus erythematosus of the Zhuang Nationality in Guangxi Province.Methods Allele polymerase chain reaction-sequence specific primers(PCR-SSP)were used to study the HLA-DRB1 allele genes in 52 patients with SLE and 70 healthy controls of the Zhuang Nationality in Guangxi Province.Results The allele frequencies of HLA-DRB1*1401 and HLA-DRB1*16 were significantly less in SLE patients than those of the controls(RR=0.28,χ2=5.00,P=0.02 and RR=0.39,χ2=3.95,P=0.05).HLA-DRB1*08,DRB1*11 and DRB1*13 alleles were not found in these two groups.Conclusion Our data suggest that the HLA-DRB1*1401 and HLA-DRB1*16 might be protecting genes for SLE in Guangxi Zhuang nationality.No susceptible gene is found in our study.

Key words: Lupus erythematosus, Systemic HLA-DR antigens