中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (6): 462-463.

• 论著 • 上一篇    下一篇

P16和视网膜母细胞瘤蛋白在高砷煤引起的砷中毒患者皮损中的表达

符刚1, 张信江1, 杜辉2, 周运书2, 袁伟1, 徐海环1, 郑庭铭1, 贾曹刚2   

  1. 1. 遵义医学院附属医院皮肤科 563003;
    2. 贵州省黔西南州疾病控制中心
  • 收稿日期:2001-12-22 出版日期:2002-12-15 发布日期:2002-12-15
  • 通讯作者: 张信江,Email:xinjiangzhang@sohu.com E-mail:xinjiangzhang@sohu.com
  • 基金资助:
    贵州省省长资金(C-197);贵州省教育厅基金(C-174)

Expression of p16 and Rb Proteins with High Arsenic Coal Intoxication

FU Gang1, ZHANG Xinjiang1, DU Hui2, ZHOU Yunshu2, YUAN Wei1, XU Haihuan1, ZHENG Tingming1, JIA Caogang2   

  1. Department of Dermatology, Affliated Hospital, Zunyi Medical College, Zunyi 563003, China
  • Received:2001-12-22 Online:2002-12-15 Published:2002-12-15

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摘要： 目的 研究P16和视网膜母细胞瘤蛋白(Rb)在高砷煤引起的砷中毒患者皮损中的表达.方法 采用免疫组化SP法检测46例高砷煤引起的砷中毒患者皮损中P16和Rb蛋白的表达.结果 高砷煤引起的砷中毒患者皮损中P16蛋白的表达缺损率为59.7%,其表达随病损的加剧而减低,并与临床分级和病理分型明显相关(P<0.01).Rb蛋白的阳性表达率为60.9%,与临床分级相关(P<0.05).P16蛋白的阳性表达与Rb蛋白呈负相关(P<0.01).结论 P16蛋白表达降低和P16-Rb通路的失活可能与高砷煤引起的砷中毒患者皮损的发生密切相关.

关键词: 砷中毒, 蛋白质P16, 视网膜母细胞瘤蛋白质

Abstract: Objective To study the expression of p16 and Rb proteins in lesions of patients with high arsenic coal poisoning. Methods Immunohistochemistry was used to assess p16 and Rb proteins expression in 46 cases of high arsenic coalpoisoning. Results Lack of expression of p16 protein was found in 59.7% of the patients. Expression of p16 protein decreased along with the aggravation of lesions and correlated signficantly with pathological types and clinical grades(P<0.01). Expression of Rb protein was identified in 60.9%of patients, and correlated with clinical grades(P<0.05). There was aninverse correlation between expression of p16 protein and that of Rb protein. Conclusion Down-regulation of p16 protein expression and inactivation of p16-Rb route may play an important role in the development of skin lesions of high arsenic coal poisoning.

Key words: Arsenic poisoning, Protein p16, Retinoblastoma protein