中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (1): 28-30.

• 论著 • 上一篇    下一篇

硬皮病患者皮损转化生长因子β1、β2 mRNA的表达

宋克敏1, 刘彤2, 瞿佩华2, 苏有明1, 杨蓉娅1   

  1. 1. 北京军区总医院皮肤科, 100700;
    2. 西安交通大学第一医院皮肤科
  • 收稿日期:2001-02-14 出版日期:2002-02-15 发布日期:2002-02-15

The mRNA Expression of Transforming Growth Factor-β1 and β2 in Lesions of Scleroderma

SONG Kemin1, LIU Tong2, QU Peihua2, SU Youming1, YANG Rongya1   

  1. Department of Dermatology, General Hospital of Beijing Military Command of PLA, Beijing 100700, China
  • Received:2001-02-14 Online:2002-02-15 Published:2002-02-15

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摘要： 目的 探讨转化生长因子(TGF)β1和β2在硬皮病发病中的作用。方法 采用原位逆转录聚合酶链反应技术检测17例硬皮病患者皮损中TGF-β1、β2mRNA的原位表达情况,并以10例正常人皮肤组织作为对照。结果 TGF-β1mRNA在硬皮病组表达阳性率和表达程度均高于对照组(P<0.05);TGF-β2mRNA在硬皮病组表达阳性率和表达程度与对照组相近(P>0.05);硬皮病皮损中TGF-β1mRNA表达阳性率和表达程度均高于TGF-β2mRNA(P<0.05).结论 TGF-β1mRNA在硬皮病皮损中高度表达,提示其在硬皮病病理纤维化的形成过程中起一定作用。

关键词: 硬皮病, 转化生长因子β

Abstract: Objective To investigate the role of transforming growth factors(TGF-β1 and β2) in the pathogenesis of scleroderma(SD). Methods The mRNA expression of TGF-β1 and β2 in the skin lesions from 17 patients with SD and skin from 10 normal controls were detected with in situ RT-PCR technique. Results A higher positive rate and stronger expression of TGF-β1 mRNA in SD skin lesions were seen, compared with those in controls(P<0.05).The difference of TGF-β2 mRNA expression between SD patients and controls was not significant (P>0.05).The higher positive rate and stronger expression of TGF-β1 mRNA than TGF-β2 mRNA in SD were seen(P<0.05). Conclusion TGF-β1 mRNA is expressed intensely in the SD lesions, which implies that it may be involved in the pathogenesis of SD.

Key words: Scleroderma, Transforming growth factor beta