中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (1): 17-19.

• 论著 • 上一篇    下一篇

系统性红斑狼疮疾病活动指数与治疗的关系探讨

满孝勇, 李学平, 冒长峙, 周晓鸿, 谢红   

  1. 昆明医学院第二附属医院皮肤科, 650101
  • 收稿日期:2001-09-13 出版日期:2002-02-15 发布日期:2002-02-15

The Significance of Systemic Lupus Erythematosus Disease Activity Index in the Treatment of SLE

MAN Xiaoyong, LI Xueping, MAO Changzhi, ZHOU Xiaohong, XIE Hong   

  1. Department of Dermatology, The Second Affiliated Hospital, Kunming Medical College, Kunming 650101, China
  • Received:2001-09-13 Online:2002-02-15 Published:2002-02-15

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摘要： 目的 探讨系统性红斑狼疮疾病活动指数(SLEDAI)对临床治疗的指导作用。方法 以SLEDAI对每一例SLE患者入院前10天内和出院时的活动性进行评价;根据患者病情分别给予泼尼松、甲泼尼龙冲击、环磷酰胺冲击治疗。以SPSS统计软件进行相应统计学分析。结果 ①入院前和出院时SLEDAI均值比较t=8.65,P<0.001;②不同治疗分数患者SLEDAI比较差异有显着性;③泼尼松用量、甲泼尼龙或CTX冲击治疗均与SLEDAI正相关;④不同的治疗方法与不同的器官/系统活动性有关。结论 SLEDAI是一较好的评价SLE活动性的指标,对临床治疗有较好的指导作用。对不同的器官/系统受累,宜选择不同的治疗方案。

关键词: 红斑狼疮,系统性, 泼尼松, 免疫抑制剂

Abstract: Objective To study the clinical significance of systemic lupus erythematosus disease activity index(SLEDAI) in the treatement of SLE. Methods Disease activity of every patient with SLE 10 days before admission and before discharging was assessed using the SLEDAI system. The patients were treated separately with prednisone, pulse methylprednisolone and/or pulse cyclophosphamide according to their conditions. Statistical analysis was carried out using SPSS software. Results ①The difference of SLEDAI between the patients before admission and discharging was significant (P<0.001). ②The difference of SLEDAI among different treatment groups was significant. ③There was a positive correlation between the dosage of prednisone, methylprednisone, cyclophosphamide and SLEDAI. ④Different treatment choice was associated with different organ/system involvement. Conclusion SLEDAI is an effective indicator in evaluating disease activity of SLE patients, which is useful in SLE treatment.

Key words: Lupus erythematosus, systemic, Prednisone, Immunosuppressive agents