中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (3): 175-177.

• 论著 • 上一篇    下一篇

1993～1998年中国十城市分离的淋球菌对抗生素的敏感性监测

全国性病麻风病控制中心   

  1. 全国性病麻风病控制中心
  • 收稿日期:2000-05-10 出版日期:2001-06-15 发布日期:2001-06-15
  • 通讯作者: 叶顺章, 全国性病麻风病控制中心, 南京210042

Surveillance of Antibiotic Susceptibility of Neisseria gonorrhoeae Isolated from Ten Cities of China from 1993～1998

YE Shunzhang   

  1. National Center for STDs and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042, China
  • Received:2000-05-10 Online:2001-06-15 Published:2001-06-15

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摘要： 目的 研究我国1993～1998年分离的淋球菌对青霉素、四环素、环丙沙星、大观霉素和头孢曲松的敏感性,作为制定治疗方案和防治对策的参考依据。方法 测定菌株对抗生素的敏感性用琼脂稀释法,测定产青霉素酶淋球菌菌株用纸片酸度法。结果 6年来,共检测了3186株淋球菌对抗生素的敏感性。发现青霉素的耐药菌百分率为66.70%,产青霉素酶淋球菌菌株占8.14%;对四环素的耐药菌株占93.02%,高度耐药的四环素耐药淋球菌菌株占4.65%。结论 我国近6年分离的淋球菌对青霉素、四环素和环丙沙星耐药菌百分率较高,对大观霉素和头孢曲松仍较敏感。

关键词: 奈瑟氏球菌,淋病, 抗生作用, 微生物敏感性试验

Abstract: Objective To investigate the antimicrobial susceptibility of Neisseria gonorrhoeae isolated from 10 cities of China, and to provide reference for the formulation of treatment guideline and making control strategy. Methods Agar dilution was used to detect antimicrobial susceptibility and acidometric method for PPNG testing. Results A total of 3186 gonococcal isolates were tested from 1993 to 1998. The resistant rate for penicillin was 66.70%. PPNG isolates accounted for 8.14%. Tetracycline-resistant isolates accounted for 93.02%, and high level tetracycline-resistant isolates (TRNG) accounted for 4.65%. The resistant rate for ciprofloxacin was also high (34.25%). The resistant rates for spectinomycin and ceftriaxone were 0.44% and 0.57% respectively. Conclusions The gonococcal isolates are highly resistant to penicillin, tetracycline, and ciprofloxacin, while still sensitive to spectinomycin and ceftriaxone. These results suggest that the present treatment for gonorrhea can still be used.

Key words: Neisseria gonorrhoeae, Gonorrhoeae, Microbial sensitivity tests