中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (6): 410-411.

• 论著 • 上一篇    下一篇

毛乳头细胞与毛发上皮细胞相互作用的研究

程波1, 伍津津2, 刘荣卿1, 麦跃1, 钟白玉1, 唐书谦1   

  1. 1. 第三军医大学西南医院皮肤科 重庆 400038;
    2. 大坪医院皮肤科
  • 收稿日期:2000-01-25 出版日期:2000-12-15 发布日期:2000-12-15
  • 基金资助:
    国家自然科学基金资助课题(39970683)

Study on Interaction of Dermal Papilla Cells and Hair Epithelial Cells

CHENG Bo1, WU Jingjing2, LIU Rongqing1   

  1. Department of Dermatology, South West Hospital, The Third Military Medical University, Chongqing 400038
  • Received:2000-01-25 Online:2000-12-15 Published:2000-12-15

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摘要： 目的 探讨人毛乳头细胞和毛发上皮细胞间的相互作用,了解毛发生长周期的调控,寻找体内外毛囊重建的途径。方法 人毛乳头细胞和毛发上皮细胞分室和共同培养于DMEM培养基中,在不同时相计数两种细胞,并观察细胞的生长方式。结果 毛乳头细胞和毛发上皮细胞的生长能相互促进,毛发上皮细胞能诱导培养的毛乳头细胞形成毛乳头样结构。结论 毛囊真-表皮间的作用是双向的,它们共同控制着毛囊的生长和发育。

关键词: 毛囊, 上皮细胞, 间质细胞

Abstract: Objective To investigate the interaction between dermal papilla cells and hair follicle epithelial cells,to understand the regulation of hair follicle growth cycle, and to find out the pathway of hair follicle reconsitution in vitro and in vivo. Method Human dermal papilla cells and hair follicle epithelial cells were cultured in the same or separated compartments.The cells were counted in different phases and the cell growth pattern was observed. Results The two kinds of cells could stimulate the proliferation each other.Human hair follicle epithelial cells could induce dermal papilla cells to aggregate and form dermal papilla-like structure. Conclusion There is a mutual interaction between the epithelial cells and dermal cells of the hair follicle.The growth and development of hair follicle is regulated by the interaction of these cells.

Key words: Hair follicle, Epithelial cells, Stromal cells