关键词: 痤疮,寻常, 性激素类, 氢化可的松

Abstract: Objective To investigate serum levels of 8 sex hormones and cortisol in women with acne vulgaris and their clinical significance. Methods The serum levels of 8 kinds of sex hormone and cortisol were measured with radioimmunoassay in the luteal phase of menstrual cycle in 54 women with acne, compared with 30 healthy controls. Results It was revealed that the levels of testosterone, androstenedione and dehydroepiandrosterone-sulfate were significantly higher in patients (3.30±2.76 nmol/L, 11.44±3.95 nmol/L, 6.79±3.88μ mol/L) than those in the controls (1.57±0.67 nmol/L, 8.66±1.47 nmol/L, 4.07±1.53μ mol/L) (P<0.01). No significant difference was found in the levels of estradiol (E₂), progesterone,prolactin, follicle-stimulating hormone and luteinizing hormone between the two groups (P>0.05). The level of cortisol was significantly decreased in patients with acne (P<0.05). A significant fall of E₂ level was observed in women with exacerbated acne before menses (P<0.05) and those who were younger than 25 years old (P<0.05). Conclusions The study indicates that the hyperandrogenaemia may be the major reason which causes and aggravates acne. The function of adrenal cortex may be associated with the pathogenesis of acne. Insufficiency of luteal function results in low level of E₂, which may play a role in exacerbation of acne before menses. The decreased E₂ due to immaturity of ovarian function could explain the tendency towards severe acne in young women.

Key words: Acne,vulgaris, Sex hormones, Hydrocortisone