中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (4): 227-228.

• 论著 • 上一篇    下一篇

特应性皮炎患者血清IgE测定及其临床意义

余碧娥, 田润梅, 康克非   

  1. 上海医科大学附属华山医院皮肤科 200040
  • 收稿日期:1999-08-27 出版日期:2000-08-15 发布日期:2000-08-15

Measurement of Serum IgE in Atopic Dermatitis and Its Clinical Significance

YU Bie, TIAN Runmei, KANG Kefei   

  1. Department of Dermatology, Huashan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1999-08-27 Online:2000-08-15 Published:2000-08-15

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摘要： 目的 探讨IgE在特应性皮炎(AD)中的作用。方法 选择确诊的AD患者57例及其双亲98例以及30例无遗传过敏史的正常人,分别检测其血清总IgE,并进行比较。结果 AD患者的IgE值明显高于正常人对照组(P<0.01)。AD伴呼吸道过敏个人史和(或)家族史者IgE值明显升高。IgE随皮损严重度增加而增加。双亲IgE值高者,其子女68.2%IgE值亦高,其中伴呼吸道过敏的子女均为高值。结论 IgE在AD的发生以及在AD的皮炎形成中可能起作用。

关键词: 皮炎,特应性, IGE

Abstract: Objective To study the role of serum IgE in atopic dermatitis(AD). Methods Fifty seven cases of AD patients, 98 parents of the patients and 30 healthy controls were selected in the investigation. The total serum IgE was measured. Results The levels of total serum IgE of AD patients were significantly higher than those of healthy controls (P<0.01). The AD patients with personal and family history of respiratory anaphylaxis tended to have higher IgE levels (P<0.01).The IgE levels were consistent with the severity of skin lesions. The levels of IgE were more likely to be high for those whose parents had high IgE levels and always much higher for those with respiratory anaphylaxis. Conclusion Serum IgE may play a part in the pathogenesis of atopic dermatitis, and the results warrant further study.

Key words: Dermatitis,atopic, IgE