中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (1): 14-16.

• 论著 • 上一篇    下一篇

环磷酰胺冲击疗法联合小剂量皮质类固醇治疗狼疮性肾炎

胡萍, 成于珈, 谷沅珉, 徐世正   

  1. 湖北医科大学附属第一医院皮肤科 武汉 430060
  • 收稿日期:1997-09-22 修回日期:1998-04-20 出版日期:1999-02-15 发布日期:1999-02-15

Clinical Evaluation on Cyclophosphamide Pulse Therapy in Combination with Small Dose of Corticosteroid for the Treatment of Lupus Nephritis

HU Ping, CHENG Yujia, GU Yuanmin   

  1. Department of Dermatology, First Affiliated Hospital, Hubei Medical University, Wuhan 430060
  • Received:1997-09-22 Revised:1998-04-20 Online:1999-02-15 Published:1999-02-15

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摘要： 目的 探讨环磷酰胺冲击疗法联合小剂量皮质类固醇激素治疗狼疮性肾炎的疗效.方法 对34例狼疮性肾炎患者使用环磷酰胺冲击疗法联合小剂量皮质类固醇激素治疗,并与25例单用皮质类固醇激素疗法进行对照观察.结果 环磷酰胺冲击疗法联合小剂量皮质类固醇激素疗法组的临床症状及免疫学指标的改善、肾功能的改善及肾衰率的降低均明显优于单用激素疗法组,且不良反应不大.结论 环磷酰胺冲击疗法联合小剂量皮质类固醇激素治疗狼疮性肾炎有较好的疗效.

关键词: 狼疮肾炎, 环磷酰胺, 皮质类固醇

Abstract: Objective To evaluate the effectiveness of cyclophosphamide pulse therapy in combination with small dose of corticosteroid for the treatment of lupus nephritis Methods Thirty four patients with lupus nephritis were treated by cyclophosphamide pulse therapy in combination with small dose of corticosteroid,compared with 25 cases of lupus nephritis treated by conventional corticosteroid therapy Results The combination therapy had better results than those of conventional corticosteroid therapy,including the improvement of the clinical manifestations,immunological indexes,renal functions,decreasing of incidence of renal failure and the frequency of side effects Conclusion Combination therapy has a better effectiveness in treating lupus nephritis.

Key words: Lupus nephritis, Cyclophosphamide, Corticosteroid