中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (5): 300-301.

• 论著 • 上一篇    下一篇

碘化钾预防孢子丝菌病的实验研究

姜兰香, 段正芳, 张民夫, 苏忠兰, 王延龙   

  1. 白求恩医科大学第二临床学院皮肤科, 长春130041
  • 收稿日期:1998-01-18 修回日期:1998-04-24 出版日期:1998-10-15 发布日期:1998-10-15
  • 基金资助:
    中华医学会皮肤科学会科研基金

Potassium Iodide in the Prevention of Sporotrichosis in Experimental Animal

Jiang Lanxiang, Duan Zhengfang, Zhang Minfu   

  1. Department of Dermatology, Second Clinical College, Norman Bethune University of Medical Sciences, Changchun 130041
  • Received:1998-01-18 Revised:1998-04-24 Online:1998-10-15 Published:1998-10-15

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摘要： 目的 研究低治疗量碘化钾对孢子丝菌病发病的影响,为预防本病提供理论依据。方法 采用含碘化钾的饮水饲养实验鼠,并设对照组,2周后行腹腔接种孢子丝菌,于接种后的第3～8周,每周分批处死实验鼠,剖检,观察发病情况、病理学改变及真菌学所见。结果 实验鼠本病的发病率显着下降(P<0.01),其下降与碘化钾的用量有关。结论 低治疗量碘化钾具有预防孢子丝菌病发病的作用。

关键词: 孢子丝菌病, 碘化钾, 预防, 实验动物

Abstract: Objective To investigate the effect of potassium iodide on the incidence of sporotrichosis, and provide the theoretical basis for the prevention of sporotrichosis. Methods Experimental mice were divided into 4 groups, group 1～3 were fed with water containing different doses of potassium iodide, and no potassium iodide was given to the control group. After two weeks, the fungi were inoculated intraperitoneally to all the mice. In the third to the eighth weeks, the mice were sacrificed every week in batches. The infection, pathological changes and mycological findings of the mice were observed. Results The incidence rate of experimental sporotrichosis was significantly decreased in the mice (P<0.01), and the decrease was related to the dosage of potassimu iodide. Conclusion The results show that potassium iodide may be of use in the prevention of sporotrichosis.

Key words: Sporotrichosis, Potassium Iodide, Prevention, Experimental animal