中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (4): 209-211.

• 论著 •    下一篇

恶性黑素瘤患者T细胞化学趋化功能

郑敏1, 孙国均1, 蔡绥1, Muller R2, Mrowietz U2   

  1. 1. 浙江医科大学第二附属医院皮肤科 310009;
    2. 德国基尔大学皮肤病医院
  • 收稿日期:1997-09-23 修回日期:1998-02-27 出版日期:1998-08-15 发布日期:1998-08-15
  • 基金资助:
    浙江省卫生厅科研基金资助

T Cell Chemotactic Response in Patients with Primary and Metastatic Malignant Melanoma

Zheng Min1, Sun Guojun1, Cai Suiqing1   

  1. Department of Dermatology, the Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009
  • Received:1997-09-23 Revised:1998-02-27 Online:1998-08-15 Published:1998-08-15

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摘要： 目的 探讨恶性黑素瘤患者循环T细胞在体外对单核细胞化学趋化蛋白1(MCP-1)的化学趋化功能及其与肿瘤浸润淋巴细胞(TIL)及与肿瘤转移之间的关系.方法 用微量化学趋化装置和免疫组化方法测定患者T细胞对MCP1的化学趋化功能和TIL计数.结果 原发性和转移性黑素瘤患者T细胞对MCP-1的化学趋化功能均明显低下,而基底细胞癌患者T细胞的化学趋化功能正常.免疫组化研究发现原发性恶性黑素瘤TIL数量与T细胞的化学趋化功能之间无关.结论 原发性和转移性恶性黑素瘤患者循环T细胞特异性地对MCP-1的化学趋化反应低下.这可能是由于这些细胞上的MCP-1受体表达或调节异常所致.

关键词: 黑色素瘤, T淋巴细胞, 趋化性

Abstract: Objective To address the question whether circulating T-cells from the patients with primary and metastatic malignant melanoma show altered chemotaxis to monocyte chemotactic protein 1 (MCP-1) and its relation to tumor infiltrating lymphocyte (TIL) and metastasis. Methods Chemotactic responsiveness of T-cells towards MCP-1 and immuno-histochemistry study were investigated in patients with primary and metastatic melanoma compared to patients with basal cell carcinoma and healthy persons. Results T-cells from primary and metastatic melanoma patients showed a significantly decreased chemotactic migration towards MCP-1 and that T-cells from patients with basal cell carcinoma showed normal chemotactic response. Immuno-histochemistry study showed that there was no correlation between the density of TIL and the decreased chemotaxis of circulating T-cells to MCP-1 in patients with primary melanoma. Conclusion Circulating T-cells from patients with primary and metastatic malignant melanoma show a MCP-1-specific decrease in chemotactic migration, this may be due to abnormal expression or modulation of MCP-1-receptor on these cells.

Key words: Melanoma, T-Lymphocytes, Chemotaxis