中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (3): 176-177.

• 论著 • 上一篇    下一篇

CD44V6在表皮肿瘤及恶性黑素瘤的表达

陈秀琴1, 徐前喜1, 林文玉1, 李荣1, 朱铁君2   

  1. 1. 北京医科大学人民医院皮肤科 100044;
    2. 北京医科大学人民医院中心实验室
  • 收稿日期:1997-11-07 修回日期:1998-03-09 出版日期:1998-06-15 发布日期:1998-06-15

Expression of CD44V6 in Human Epidermal Tumours and Malignant Melanoma

Chen Xiuqin1, Xu Qianxi1, Lin Wenyu1   

  1. Department of Dermatology, People's Hospital, Beijing Medical University, Beijing 100044
  • Received:1997-11-07 Revised:1998-03-09 Online:1998-06-15 Published:1998-06-15

PDF

298

赞

摘要： 目的 研究CD44V6在鳞状细胞癌、基底细胞癌和恶性黑素瘤的表达.方法 免疫组织化学对石蜡包埋组织标本进行检测.结果 10例鳞状细胞癌CD44V6膜表达阳性,且随癌细胞分化程度降低CD44V6表达下调.10例基底细胞癌和8例恶性黑素瘤不表达CD44V6.结论 CD44V6的表达与皮肤肿瘤的类型有关

关键词: CD44V6, 鳞状细胞癌, 基底细胞瘤, 恶性黑素瘤

Abstract: Objective To study the expression of CD44V6 in human epidermal tumours and malignant melanoma.Methods The expression of CD44V6 was detected by an immunohistochemical technique in squamous cell carcinoma(SCC),basal cell carcinoma(BCC) and malignant melanoma(MM).Results CD44V6 was expressed on the membrane of tumour cells of 10 patients with SCC,and there was downregulation of CD44V6 expression which along with the decrease of differentiation of SCC tumour cells.Tumour cells of 8 patients with MM and 10 patients with BCC did not express CD44V6.Conclusion Our findings suggest that CD44V6 expression is correlated with the types of skin tumours.

Key words: CD44V6, Squamous cell carcinoma, Basal cell carcinoma, Malignant melanoma