中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (3): 166-167.

• 论著 • 上一篇    下一篇

不同时期分离的淋病奈瑟菌药物敏感性测定

向辉1, 雍刚2, 叶梅君1, 李绍兴2, 周蓉1, 廖巫山2, 周启贵2   

  1. 1. 华西医科大学公共卫生学院 成都 610041;
    2. 四川省皮肤病性病防治研究所
  • 收稿日期:1997-09-26 修回日期:1998-01-04 出版日期:1998-06-15 发布日期:1998-06-15
  • 基金资助:
    四川省科委和四川省卫生厅基金共同资助

Study on Susceptibility of Neisseria Gonorrhoeae Isolated from Chengdu in Different Periods

Xiang Hui1, Yong Gang2, Ye Meijun1   

  1. The College of Public Health, West China University of Medical Sciences, Chengdu 610041
  • Received:1997-09-26 Revised:1998-01-04 Online:1998-06-15 Published:1998-06-15

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摘要： 目的 了解淋病奈瑟菌对抗生素敏感性的变迁情况.方法 对门诊1991年和1996年各100株标本进行了12种抗生素最小抑菌浓度(MIC)测定.同时对产青霉素酶株(PPNG)和非产青霉素酶株(nonPPNG)的MIC值进行了比较.结果与结论 青霉素G、四环素等6种抗生素MIC值1996年与1991年两者之间有显著性差异(P<0.05或P<0.01).其中MIC50值变化较大的是青霉素G和氟哌酸,1996年比1991年均增加63倍.此外,PPNG株和nonPPNG株MIC值也存在差异.

关键词: 淋病奈瑟菌, 微生物敏感性试验

Abstract: Objective To study the changes of susceptibilities of Neisseria gonorrhoeae to antibiotics in Chengdu area.Methods The MIC values of 12 antibiotics to 100 strains in 1991 and 100 strains in 1996 were determined,and the MIC values to PPNG and non-PPNG strains were also compared.Results and Conclusion The MIC values of 6 antibiotics (including penicillin G,tetracycline,etc.) to the isolates in different periods changed significantly (P<0.05 or P<0.01),and among them the values of MIC50 of penicillin G and norfloxacin in 1996 had a 63 fold increase over those in 1991.Moreover,there was a difference in MIC values between PPNG and non-PPNG strains.

Key words: Neisseria gonorrhoeae, Microbial sensitivity tests