中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (6): 392-394.

• 论著 • 上一篇    下一篇

麻风菌素试验和血清抗体检测联合监测麻风高危人群

沈建平1, 李文忠1, 魏万惠1, 严良斌1, 叶干运1, 黄文标2, 刘凤梧2, 冉顺鹏3, 刘聪华3, 陆世学3, 李廷光3, 徐光恒3, 张加荣3   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042;
    2. 云南省皮肤病防治研究所;
    3. 云南省文山州皮肤病防治研究所暨协作皮防站
  • 收稿日期:1996-10-07 修回日期:1996-12-26 出版日期:1997-12-15 发布日期:1997-12-15

Monitoring High Risk Group of Leprosy by Lepromin Test and Serologic Test

Shen Jianping1, Li Wenzhong1, Wei Wanhui1   

  1. Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, Nanjing 210042
  • Received:1996-10-07 Revised:1996-12-26 Online:1997-12-15 Published:1997-12-15

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摘要： 为了早期发现麻风患者,应用麻风菌素试验和血清抗体检测方法在云南省文山州分别监测192例和106例初次检测抗ND-BSA抗体阳性的自然人群和麻风患者家属发病情况,时间2年.在麻风菌素反应阴性和血清抗体阳性的自然人群和患者家属中分别发现1例和3例多菌型麻风.认为麻风菌素阴性和血清抗体持续阳性是发病的危险因素.两种方法相结合可鉴定出高危对象.此法在多菌型患者发病率较高的村庄可应用,有助于早期发现患者.考虑到费用较高,此法不推荐作为常规手段用于低流行区的麻风防治.

关键词: 麻风, 麻风菌素试验, 血清学试验

Abstract: In order to detect leprosy patients early, 192 residents and 106 leprosy household contacts with positive anti-ND-BSA antibodies in Wenshan Prefecture, Yunnan Province were followed up with lepromin test and serologic test, for 2 years. The results showed that 1 and 3 multibacillary cases were detected in residents and leprosy household contacts with negative lepromin test and positive anti-ND-BSA antibody, respectively. The results suggested that both lepromin test negativity and antibody persistent positivity were high risk factors in developing clinical disease. The authors consider that the combination of these two tests may be useful to identify high risk group of leprosy in high-endemic villages of leprosy for the early detection of patients with leprosy. But it is not recommended as a routine measure to be used in a low endemic region due to its high cost and low effectiveness.

Key words: Leprosy, Serologic test, Lepromin test