中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (6): 371-373.

• 论著 • 上一篇    下一篇

在基底细胞癌和鳞状细胞癌皮损中bcl-2与Fas蛋白的表达

王秀丽, 徐世正, 熊腊元   

  1. 湖北医科大学附属第一医院皮肤科 武汉 430060
  • 收稿日期:1996-12-26 修回日期:1997-06-27 出版日期:1997-12-15 发布日期:1997-12-15

Expression of bcl-2 and Fas Protein in the Lesions of Basal Cell Carcinoma and Squamous Cell Carcinoma

Wang Xiuli, Xu Shizheng, Xiong Layuan   

  1. Department of Dermatology, First Affilliated Hospital, Hubei Medical University, Wuhan 430060
  • Received:1996-12-26 Revised:1997-06-27 Online:1997-12-15 Published:1997-12-15

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摘要： 为了探讨细胞凋亡抑制基因bcl-2(B-cell lymphoma/leukemia 2)及凋亡基因Fas与皮肤基底细胞癌(BCC)及鳞状细胞癌(SCC)发生、发展的关系,对13例BCC及11例SCC皮损进行了bcl-2蛋白和Fas抗原的免疫组化研究.11例SCC中Ⅰ级6例、Ⅱ级3例、Ⅲ级2例.结果13例BCC肿瘤组织全层bcl-2均染色阳性,而无任何Fas阳性着色;11例SCC无1例bcl-2染色阳性,却全部出现Fas阳性细胞,且Fas的表达强度与肿瘤分化程度呈正相关.该结果证明:bcl-2表达见于BCC,而不见于SCC;Fas表达则见于SCC,而不见于BCC.这种区别反映出两种皮肤肿瘤在发病机理上的差异.

关键词: bcl-2, Fas, 癌,基底细胞, 癌,鳞状细胞

Abstract: To investigate the relationship between the apoptosis-suppressing gene bcl-2 and apoptosis gene Fas and the occurrence and development of basal cell carcinoma (BCC) and squamous cell carcinoma(SCC) in human skin, we performed the immunohistochemical staining for bcl-2 and Fas expression in 13 cases of BCC and 11 cases of SCC. Among the SCCs, according to Broders' classification, 6 cases were grade Ⅰ, 3 grade Ⅱ, and 2 grade Ⅲ. The results showed that all 13 BCC cases expressed strong cytoplasmic bcl-2 positive staining throughout the BCC tissues, but no Fas positive staining in the BCC tumor cells. All 11 SCC tumor tissues expressed positive Fas in the cell membranes, and the intensity of Fas expression was positively correlated with the degree of tumor differentiation, but did not express bcl-2. Conclusion: Our preliminary results suggest that the bcl-2 expression is consistently positive in BCCs, but not in SCCs, while the Fas expression is consistently positive in SCCs, but not in BCCs. The difference of bcl-2 and Fas expression may reflect the different pathogenesis of BCC and SCC.

Key words: bcl-2, Fas, Carcinomam,basal cell, Carcinoma,squamous cell